E
Elphège P. Nora
Researcher at University of California, San Francisco
Publications - 51
Citations - 7716
Elphège P. Nora is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: CTCF & Chromatin. The author has an hindex of 23, co-authored 44 publications receiving 6133 citations. Previous affiliations of Elphège P. Nora include Cold Spring Harbor Laboratory & Curie Institute.
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Journal ArticleDOI
The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA
Erik Splinter,Elzo de Wit,Elphège P. Nora,Petra Klous,Harmen J.G. van de Werken,Yun Zhu,Lucas J.T. Kaaij,Wilfred F. J. van IJcken,Joost Gribnau,Edith Heard,Wouter de Laat +10 more
TL;DR: It is found that loci on the active X form multiple long-range interactions, with spatial segregation of active and inactive chromatin, and a role for Xist RNA in shaping the conformation of the inactive X chromosome at least partially independent of transcription.
Journal ArticleDOI
The pluripotent genome in three dimensions is shaped around pluripotency factors
Elzo de Wit,Britta A M Bouwman,Yun Zhu,Petra Klous,Erik Splinter,Marjon J.A.M. Verstegen,Peter H.L. Krijger,Nicola Festuccia,Elphège P. Nora,Maaike Welling,Edith Heard,Niels Geijsen,Raymond A. Poot,Ian Chambers,Wouter de Laat +14 more
TL;DR: It is concluded that pluripotent stem cells have a unique higher-order genome structure shaped by pluripotency factors, and it is speculated that this interactome enhances the robustness of the pluripresent state.
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RNA Interference Guides Histone Modification during the S Phase of Chromosomal Replication
TL;DR: These results explain how "silent" heterochromatin can be transcribed and lead to a model for epigenetic inheritance during replication, providing a plausible mechanism for epigenetics phenomena that depend on replication and temperature, such asvernalization in plants and position effect variegation in animals.
Journal ArticleDOI
Sensing X Chromosome Pairs Before X Inactivation via a Novel X-Pairing Region of the Xic
Sandrine Augui,Guillaume J. Filion,S. Huart,Elphège P. Nora,M. Guggiari,M. Maresca,A. F. Stewart,Edith Heard +7 more
TL;DR: It is proposed that homologous associations driven by this novel X-pairing region (Xpr) of the Xic enable a cell to sense that more than one X chromosome is present and coordinate reciprocal Xist/Tsix expression.
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HiTC: exploration of high-throughput 'C' experiments.
Nicolas Servant,Bryan R. Lajoie,Elphège P. Nora,Luca Giorgetti,Chong-Jian Chen,Edith Heard,Job Dekker,Emmanuel Barillot +7 more
TL;DR: The R/Bioconductor package HiTC facilitates the exploration of high-throughput 3C-based data and allows users to import and export 'C' data, to transform, normalize, annotate and visualize interaction maps.