E
Edith Heard
Researcher at European Bioinformatics Institute
Publications - 206
Citations - 27454
Edith Heard is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: X-inactivation & XIST. The author has an hindex of 75, co-authored 196 publications receiving 23899 citations. Previous affiliations of Edith Heard include Mines ParisTech & Pasteur Institute.
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Journal ArticleDOI
Spatial partitioning of the regulatory landscape of the X-inactivation centre
Elphège P. Nora,Bryan R. Lajoie,Edda G. Schulz,Luca Giorgetti,Luca Giorgetti,Luca Giorgetti,Ikuhiro Okamoto,Ikuhiro Okamoto,Ikuhiro Okamoto,Nicolas Servant,Nicolas Servant,Nicolas Servant,Tristan Piolot,Tristan Piolot,Tristan Piolot,Nynke L. van Berkum,Johannes Meisig,John W. Sedat,Joost Gribnau,Emmanuel Barillot,Emmanuel Barillot,Emmanuel Barillot,Nils Blüthgen,Job Dekker,Edith Heard,Edith Heard,Edith Heard +26 more
TL;DR: In addition to uncovering a new principle of cis-regulatory architecture of mammalian chromosomes, this study sets the stage for the full genetic dissection of the mouse X-inactivation centre.
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Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
Masashi Narita,Sabrina Nuñez,Sabrina Nuñez,Edith Heard,Masako Narita,Athena W. Lin,Stephen Hearn,David L. Spector,Gregory J. Hannon,Scott W. Lowe +9 more
TL;DR: A distinct heterochromatic structure that accumulates in senescent human fibroblasts is described, which is designated senescence-associated heterochROMatic foci (SAHF) and is associated with the stable repression of E2F target genes.
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HiC-Pro: an optimized and flexible pipeline for Hi-C data processing
Nicolas Servant,Nelle Varoquaux,Nelle Varoquaux,Nelle Varoquaux,Bryan R. Lajoie,Eric Viara,Chong-Jian Chen,Jean-Philippe Vert,Jean-Philippe Vert,Jean-Philippe Vert,Edith Heard,Edith Heard,Edith Heard,Job Dekker,Emmanuel Barillot,Emmanuel Barillot,Emmanuel Barillot +16 more
TL;DR: This work applied HiC-Pro to different Hi-C datasets, demonstrating its ability to easily process large data in a reasonable time and its fast implementation of the iterative correction method.
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Transgenerational Epigenetic Inheritance: myths and mechanisms
TL;DR: Although the inheritance of epigenetic characters can certainly occur-particularly in plants-how much is due to the environment and the extent to which it happens in humans remain unclear.
Journal ArticleDOI
Systematic Discovery of Xist RNA Binding Proteins
Ci Chu,Ci Chu,Qiangfeng Cliff Zhang,Simão Teixeira da Rocha,Ryan A. Flynn,Maheetha Bharadwaj,J. Mauro Calabrese,Terry Magnuson,Edith Heard,Howard Y. Chang +9 more
TL;DR: ChIRP-MS analysis of four ncRNAs captures key protein interactors, including a U1-specific link to the 3' RNA processing machinery, which engages with proteins in a modular and developmentally controlled manner to coordinate chromatin spreading and silencing.