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Paolo Scudieri
Researcher at Istituto Giannina Gaslini
Publications - 56
Citations - 980
Paolo Scudieri is an academic researcher from Istituto Giannina Gaslini. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 36 publications receiving 673 citations. Previous affiliations of Paolo Scudieri include University of Genoa.
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Journal ArticleDOI
Association of TMEM16A chloride channel overexpression with airway goblet cell metaplasia
Paolo Scudieri,Emanuela Caci,Silvia Bruno,Loretta Ferrera,Marco Schiavon,Elvira Sondo,Valeria Tomati,Ambra Gianotti,Olga Zegarra-Moran,Nicoletta Pedemonte,Federico Rea,Roberto Ravazzolo,Roberto Ravazzolo,Luis J. V. Galietta +13 more
TL;DR: In bronchial epithelial cells treated with interleukin‐4, it is found that TMEM16A protein becomes highly expressed in goblet but not in ciliated cells.
Journal ArticleDOI
Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms.
Paolo Scudieri,Emanuela Caci,Arianna Venturini,Elvira Sondo,Giulia Pianigiani,Carla Marchetti,Roberto Ravazzolo,Roberto Ravazzolo,Franco Pagani,Luis J. V. Galietta +9 more
TL;DR: Introduction of an activating mutation in TMEM16F sequence caused a marked increase in phosphatidylserine scrambling and in ion transport indicating direct involvement of the protein in both functions.
Journal ArticleDOI
Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release
Giulia Gorrieri,Paolo Scudieri,Emanuela Caci,Marco Schiavon,Valeria Tomati,Francesco Sirci,Francesco Napolitano,Diego Carrella,Ambra Gianotti,Ilaria Musante,Maria Favia,Valeria Casavola,Lorenzo Guerra,Federico Rea,Roberto Ravazzolo,Roberto Ravazzolo,Diego di Bernardo,Luis J. V. Galietta +17 more
TL;DR: It is suggested that Th-2 cytokines induce a profound change in expression and function in multiple ion channels and transporters that results in enhanced bicarbonate transport ability.
Journal ArticleDOI
The anoctamin family: TMEM16A and TMEM16B as calcium‐activated chloride channels
TL;DR: The question of the molecular identity of CaCCs has apparently been resolved with the identification of TMEM16A protein (also known as anoctamin‐1), which is associated with the appearance of Ca2+‐ and voltage‐dependent Cl− currents with properties similar to those of native Ca CCs.
Journal ArticleDOI
Increased expression of ATP12A proton pump in cystic fibrosis airways
Paolo Scudieri,Ilaria Musante,Emanuela Caci,Arianna Venturini,P. Morelli,Christine Walter,Davide Tosi,Alessandro Palleschi,Pablo Martín-Vasallo,Isabelle Sermet-Gaudelus,Gabrielle Planelles,Gabrielle Planelles,Gilles Crambert,Gilles Crambert,Luis J. V. Galietta +14 more
TL;DR: Proton secretion mediated by ATP12A protein on the surface of the airway epithelium may contribute to cystic fibrosis (CF) lung disease by favoring bacterial infection and airway obstruction and its importance as a possible therapeutic target is noted.