E
Emilia Peuhu
Researcher at University of Turku
Publications - 46
Citations - 1824
Emilia Peuhu is an academic researcher from University of Turku. The author has contributed to research in topics: Integrin & Breast cancer. The author has an hindex of 15, co-authored 39 publications receiving 1531 citations. Previous affiliations of Emilia Peuhu include Turku University Hospital & Åbo Akademi University.
Papers
More filters
Journal ArticleDOI
Targeting of porous hybrid silica nanoparticles to cancer cells.
Jessica M. Rosenholm,Annika Meinander,Annika Meinander,Emilia Peuhu,Rasmus Niemi,John E. Eriksson,Cecilia Sahlgren,Mika Lindén +7 more
TL;DR: The biospecifically tagged hybrid PEI-silica particles were shown to be noncytotoxic and able to specifically target folate receptor-expressing cancer cells also under coculture conditions.
Journal ArticleDOI
Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems.
TL;DR: The presented hybrid carrier system exhibits both cancer cell-targeting ability and capacity to retain a hydrophobic agent with subsequent specific release into the endosomal compartment, making the particles promising candidates as carriers for targeted drug delivery for cancer treatment.
Journal ArticleDOI
Mesoporous Silica Nanoparticles as Drug Delivery Systems for Targeted Inhibition of Notch Signaling in Cancer
Veronika Mamaeva,Jessica M. Rosenholm,Laurel T. Bate-Eya,Lotta Bergman,Emilia Peuhu,Alain Duchanoy,Lina E. Fortelius,Sebastian K.-J. Landor,Diana M. Toivola,Mika Lindén,Cecilia Sahlgren +10 more
TL;DR: A novel approach, using imagable mesoporous silica nanoparticles (MSNPs) as vehicles for targeted delivery of GSIs to block Notch signaling is presented, highlighting MSNPs as an attractive platform for targeted drug delivery of anticancer drugs with otherwise restricted clinical application.
Journal ArticleDOI
Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors.
Jessica M. Rosenholm,Emilia Peuhu,Laurel T. Bate-Eya,John E. Eriksson,Cecilia Sahlgren,Mika Lindén +5 more
TL;DR: Enhanced cancer-cell apoptosis (programmed cell death) relative to free MTX is thus observed at particle concentrations where nonspecific MTX-induced apoptosis is not observed in the nontargeted healthy cell line, while corresponding amounts of free drug affect both cell lines equally.
Journal ArticleDOI
L-type calcium channels regulate filopodia stability and cancer cell invasion downstream of integrin signalling
Guillaume Jacquemet,Habib Baghirov,Maria Georgiadou,Harri Sihto,Emilia Peuhu,Pierre Cettour-Janet,Tao He,Merja Perälä,Pauliina Kronqvist,Heikki Joensuu,Johanna Ivaska +10 more
TL;DR: It is proposed that cycles of filopodia stabilization, followed by maturation into focal adhesions, directs cancer cell migration and invasion.