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Emily K. Lehrman
Researcher at Boston Children's Hospital
Publications - 7
Citations - 3937
Emily K. Lehrman is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Synapse & Synaptic pruning. The author has an hindex of 6, co-authored 7 publications receiving 3018 citations. Previous affiliations of Emily K. Lehrman include Harvard University.
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Journal ArticleDOI
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.
Dorothy P. Schafer,Emily K. Lehrman,Amanda G. Kautzman,Ryuta Koyama,Alan R. Mardinly,Ryo Yamasaki,Richard M. Ransohoff,Michael E. Greenberg,Ben A. Barres,Beth Stevens +9 more
TL;DR: It is shown that microglia engulf presynaptic inputs during peak retinogeniculate pruning and that engulfment is dependent upon neural activity and themicroglia-specific phagocytic signaling pathway, complement receptor 3(CR3)/C3.
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The "quad-partite" synapse: microglia-synapse interactions in the developing and mature CNS.
TL;DR: Current knowledge sheds new light on the critical functions of these mysterious cells in synapse development and function in the healthy CNS, but has also incited several new and interesting questions that remain to be explored.
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Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts
Ken H. Loh,Philipp Stawski,Austin S. Draycott,Namrata D. Udeshi,Emily K. Lehrman,Daniel K. Wilton,Tanya Svinkina,Thomas J. Deerinck,Mark H. Ellisman,Beth Stevens,Steven A. Carr,Alice Y. Ting,Alice Y. Ting +12 more
TL;DR: This work mapped the proteomes of two of the most common excitatory and inhibitory synaptic clefts in living neurons and identified Mdga2 as a potential specificity factor influencing Neuroligin-2's recruitment of presynaptic neurotransmitters at inhibitory synapses.
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CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development
Emily K. Lehrman,Daniel K. Wilton,Elizabeth Y. Litvina,Christina A. Welsh,Stephen T. Chang,Arnaud Frouin,Alec J. Walker,Molly Heller,Hisashi Umemori,Chinfei Chen,Beth Stevens,Beth Stevens +11 more
TL;DR: Results demonstrate that CD47-SIRPα signaling prevents excess microglial phagocytosis and show that molecular brakes can be regulated by activity to protect specific inputs.
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An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons.
TL;DR: This protocol is an engulfment assay developed to visualize and quantify microglia-mediated engulfment of presynaptic inputs in the developing mouse retinogeniculate system and may be used to assess other phagocytes throughout the brain and the rest of the body.