E
Emmanuelle Deniaud
Researcher at French Institute of Health and Medical Research
Publications - 2
Citations - 169
Emmanuelle Deniaud is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Sp1 transcription factor & Transcription factor. The author has an hindex of 2, co-authored 2 publications receiving 151 citations.
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Overexpression of Sp1 transcription factor induces apoptosis
Emmanuelle Deniaud,Joël Baguet,Joël Baguet,Anne-Laure Mathieu,Anne-Laure Mathieu,Gilles Pagès,Jacqueline Marvel,Jacqueline Marvel,Yann Leverrier,Yann Leverrier +9 more
TL;DR: It is shown that Sp1 levels in untransformed cells must be tightly regulated as Sp1 overexpression leads to the induction of apoptosis, and that cancer cells overexpressing Sp1 can avoid Sp1-induced apoptosis.
Journal ArticleDOI
Overexpression of Transcription Factor Sp1 Leads to Gene Expression Perturbations and Cell Cycle Inhibition
Emmanuelle Deniaud,Joël Baguet,Roxane Chalard,Roxane Chalard,Bariza Blanquier,Lilia Brinza,Julien Meunier,Julien Meunier,Marie-Cécile Michallet,Aurélie Laugraud,Claudette Ah-Soon,Anne Wierinckx,Marc Castellazzi,Joël Lachuer,Christian Gautier,Jacqueline Marvel,Yann Leverrier +16 more
TL;DR: It is shown that the binding to DNA of overexpressed Sp1 induces an inhibition of cell cycle progression that precedes apoptosis and a transcriptional response targeting genes containing Sp1 binding sites in their promoter or not suggesting both direct Sp1-driven transcription and indirect mechanisms.