Marc Castellazzi

TL;DR: Avian primary cells transformed by either Jun : Fra2 or Jun‬:‬ATF2 thus provide powerful tools for the investigation of the downstream pathways involved in oncogenesis, and further genetic studies with Jun dimerization mutants will be required to be precise and extend the specific roles of the Jun’s:”Fos and Jun”:’ATF dimers during cancer progression in avian and mammalian systems.

TL;DR: Observations establish for the first time that HBZ by intervening in the re-activation of telomerase, may contribute to the development and maintenance of the leukemic process.

TL;DR: Data show that Jun-dependent cell transformation can be resolved into at least two distinct and independent processes, anchorage and growth factor independence, obviously triggered by two classes of Jun heterodimers likely regulating different sets of target genes.

TL;DR: It is shown that the binding to DNA of overexpressed Sp1 induces an inhibition of cell cycle progression that precedes apoptosis and a transcriptional response targeting genes containing Sp1 binding sites in their promoter or not suggesting both direct Sp1-driven transcription and indirect mechanisms.

TL;DR: The results suggest that ATF3 might induce growth factor independence by down-regulating a subset of the genes repressed by v-Jun, including those coding for the extracellular components fibronectin, decorin, thrombospondin 2, and the pro-apoptotic protein Par-4.