E
Enrico Cristante
Researcher at UCL Institute of Ophthalmology
Publications - 9
Citations - 221
Enrico Cristante is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Vascular endothelial growth factor A & Vascular endothelial growth factor. The author has an hindex of 7, co-authored 9 publications receiving 161 citations.
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Journal ArticleDOI
Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65
Anastasios Georgiadis,Yanai Duran,Joana Ribeiro,Laura Abelleira-Hervas,Scott J Robbie,B Sünkel-Laing,S Fourali,Anai Gonzalez-Cordero,Enrico Cristante,Michel Michaelides,Michel Michaelides,James W B Bainbridge,James W B Bainbridge,Alexander J. Smith,Robin R. Ali,Robin R. Ali +15 more
TL;DR: It is concluded that the demand for RPE65 in humans is not fully met by current vectors, and it is predicted that a more powerful vector will provide more durable benefit.
Journal ArticleDOI
Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models
Sidath E. Liyanage,Peter Gardner,Joana Ribeiro,Enrico Cristante,Robert D. Sampson,Ulrich F O Luhmann,Robin R. Ali,James W B Bainbridge +7 more
TL;DR: A reproducible flow cytometry gating approach is validated to characterize myeloid cells in several commonly used models of ocular inflammation, and the value of this strategy in identifying phenotypic differences using Ccr2-deficient mice is highlighted.
Journal ArticleDOI
Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization—Brief Report
Sidath E. Liyanage,Alessandro Fantin,Pilar Villacampa,Clemens Lange,Laura Denti,Enrico Cristante,Alexander J. Smith,Robin R. Ali,Ulrich F O Luhmann,James W B Bainbridge,Christiana Ruhrberg +10 more
TL;DR: The finding that myeloid cells are not a significant local source of VEGF in these rodent models of ONV suggests that myeeloid function in neovascular eye disease differs from skin wound healing and other neov vascular pathologies.
Journal ArticleDOI
Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization.
Giulia De Rossi,Giulia De Rossi,Maria Vähätupa,Enrico Cristante,Samantha Arokiasamy,Sidath E. Liyanage,Ulrike May,Laura Pellinen,Hannele Uusitalo-Jarvinen,James W B Bainbridge,Tero A. H. Järvinen,James R. Whiteford +11 more
Journal ArticleDOI
Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age.
Philipp Herrmann,Jill A. Cowing,Enrico Cristante,Sidath E. Liyanage,Joana Ribeiro,Yanai Duran,Laura Abelleira Hervas,Livia S. Carvalho,James W B Bainbridge,James W B Bainbridge,Ulrich F O Luhmann,Robin R. Ali,Robin R. Ali +12 more
TL;DR: Cd59a deficiency leads to a preferential age-related dysregulation of the complement system in the RPE-choroid, that alone or in combination with light as a trigger, is not sufficient to cause choroidal vascular changes or retinal degeneration and dysfunction.