C
Christiana Ruhrberg
Researcher at UCL Institute of Ophthalmology
Publications - 125
Citations - 13730
Christiana Ruhrberg is an academic researcher from UCL Institute of Ophthalmology. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor A. The author has an hindex of 48, co-authored 113 publications receiving 12195 citations. Previous affiliations of Christiana Ruhrberg include National Institute for Medical Research & Lincoln's Inn.
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Journal ArticleDOI
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Holger Gerhardt,Matthew Golding,Marcus Fruttiger,Christiana Ruhrberg,Andrea Lundkvist,Alexandra Abramsson,Michael Jeltsch,Christopher A. Mitchell,Kari Alitalo,David T. Shima,Christer Betsholtz +10 more
TL;DR: It is shown here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts.
Journal ArticleDOI
Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction
Alessandro Fantin,Joaquim M. Vieira,Gaia Gestri,Laura Denti,Quenten Schwarz,Sergey V. Prykhozhij,Francesca Peri,Stephen W. Wilson,Christiana Ruhrberg +8 more
TL;DR: It is shown that tissue macrophages promote tip cell fusion downstream of VEGF-mediated tip cell induction, and that they could equally well be exploited to stimulate tissue vascularization in ischemic disease.
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Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis
Christiana Ruhrberg,Holger Gerhardt,Matthew Golding,Rose Watson,Sofia Ioannidou,Hajime Fujisawa,Christer Betsholtz,David T. Shima +7 more
TL;DR: It is concluded that differential VEGF-A isoform localization in the extracellular space provides a control point for regulating vascular branching pattern.
Journal ArticleDOI
Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair
Sik Lee,Sarah C. Huen,Hitoshi Nishio,Hitoshi Nishio,Saori Nishio,Saori Nishio,Heung Kyu Lee,Heung Kyu Lee,Bum Soon Choi,Christiana Ruhrberg,Lloyd G. Cantley +10 more
TL;DR: Macrophages undergo a switch from a proinflammatory to a trophic phenotype that supports the transition from tubule injury to tubule repair, and this study shows that proinflammatory macrophages worsen kidney damage.
Journal ArticleDOI
Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport
Majid Hafezparast,Rainer Klocke,Christiana Ruhrberg,Andreas Marquardt,Azlina Ahmad-Annuar,Samantha Bowen,Giovanna Lalli,Abi S. Witherden,Holger Hummerich,Sharon E. Nicholson,P. Jeffrey Morgan,Ravi Oozageer,John V. Priestley,Sharon Averill,V.R. King,Simon T. Ball,Jo Peters,Takashi Toda,Ayumu Yamamoto,Yasushi Hiraoka,Martin Augustin,Dirk Korthaus,Sigrid Wattler,Philipp Wabnitz,Carmen Dickneite,Stefan Lampel,Florian Boehme,Gisela Peraus,Andreas Popp,Martina Rudelius,Juergen Schlegel,Helmut Fuchs,Martin Hrabé de Angelis,Giampietro Schiavo,David T. Shima,Andreas Russ,Gabriele Stumm,Joanne E. Martin,Elizabeth M. C. Fisher +38 more
TL;DR: It is shown that missense point mutations in the cytoplasmic dynein heavy chain result in progressive motor neuron degeneration in heterozygous mice, and in homozygotes this is accompanied by the formation of Lewy-like inclusion bodies, thus resembling key features of human pathology.