H
Helen C. Causton
Researcher at Columbia University Medical Center
Publications - 44
Citations - 10067
Helen C. Causton is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Microarray databases & Gene. The author has an hindex of 27, co-authored 44 publications receiving 9746 citations. Previous affiliations of Helen C. Causton include Massachusetts Institute of Technology & Imperial College London.
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Journal ArticleDOI
Minimum information about a microarray experiment (MIAME)-toward standards for microarray data.
Alvis Brazma,Pascal Hingamp,John Quackenbush,Gavin Sherlock,Paul T. Spellman,Chris Stoeckert,John Aach,Wilhelm Ansorge,Catherine A. Ball,Helen C. Causton,Terry Gaasterland,Patrick Glenisson,Frank C. P. Holstege,Irene F. Kim,Victor Markowitz,John C. Matese,Helen Parkinson,Alan J. Robinson,Ugis Sarkans,Steffen Schulze-Kremer,Jason E. Stewart,Ronald C. Taylor,Jaak Vilo,Martin Vingron +23 more
TL;DR: The ultimate goal of this work is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools.
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Remodeling of Yeast Genome Expression in Response to Environmental Changes
Helen C. Causton,Bing Ren,Sang Seok Koh,Christopher T. Harbison,Elenita I. Kanin,Ezra G. Jennings,Tong Ihn Lee,Heather L. True,Eric S. Lander,Richard A. Young +9 more
TL;DR: The results of expression analysis with MSN2/MSN4 mutants support the model that the Msn2/Msn4 activators induce the common response to environmental change and extend the understanding of the role of activators in effecting this response.
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Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease
Norbert Hubner,Caroline A. Wallace,Heike Zimdahl,Enrico Petretto,Herbert Schulz,Fiona Maciver,Michael Mueller,Oliver Hummel,Jan Monti,Vaclav Zidek,Alena Musilova,Vladimir Kren,Vladimir Kren,Helen C. Causton,Laurence Game,Gabriele Born,Sabine Schmidt,Anita Müller,Stuart A. Cook,Theodore W. Kurtz,John C. Whittaker,Michal Pravenec,Michal Pravenec,Timothy J. Aitman +23 more
TL;DR: This work mapped cis- and trans-regulatory control elements for expression of thousands of genes across the genome in the BXH/HXB panel of rat recombinant inbred strains and generated a data set of 73 candidate genes for hypertension that merit testing in human populations.
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An integrated approach to uncover drivers of cancer.
Uri David Akavia,Oren Litvin,Jessica J. Kim,Jessica J. Kim,Felix Sanchez-Garcia,Dylan Kotliar,Helen C. Causton,Panisa Pochanard,Panisa Pochanard,Eyal Mozes,Levi A. Garraway,Levi A. Garraway,Dana Pe'er +12 more
TL;DR: A computational framework is developed that integrates chromosomal copy number and gene expression data for detecting aberrations that promote cancer progression and correctly identified known drivers of melanoma and predicted multiple tumor dependencies.
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Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast
John J. Wyrick,Frank C.P. Holstege,Ezra G. Jennings,Helen C. Causton,David Shore,Michael Grunstein,Eric S. Lander,Richard A. Young +7 more
TL;DR: The results indicate that histones make Sir-independent contributions to telomeric silencing, and that the role of histones located elsewhere in chromosomes is gene specific rather than generally repressive.