J
Jose M. Polo
Researcher at Discovery Institute
Publications - 133
Citations - 10766
Jose M. Polo is an academic researcher from Discovery Institute. The author has contributed to research in topics: Induced pluripotent stem cell & Reprogramming. The author has an hindex of 41, co-authored 108 publications receiving 8879 citations. Previous affiliations of Jose M. Polo include Howard Hughes Medical Institute & Harvard University.
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Journal ArticleDOI
Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
Jose M. Polo,Susanna Liu,Maria E. Figueroa,Warakorn Kulalert,Sarah Eminli,Kah Yong Tan,Effie Apostolou,Matthias Stadtfeld,Yushan Li,Toshihiro Shioda,Sridaran Natesan,Amy J. Wagers,Ari Melnick,Todd Evans,Konrad Hochedlinger +14 more
TL;DR: It is shown that iPSCs obtained from mouse fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns, and it is demonstrated that cellular origin influences the in vitro differentiation potentials of iPSC into embryoid bodies and different hematopsic cell types.
Journal ArticleDOI
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
Jochen Utikal,Jose M. Polo,Matthias Stadtfeld,Nimet Maherali,Warakorn Kulalert,Ryan M. Walsh,Adam Khalil,James G. Rheinwald,Konrad Hochedlinger +8 more
TL;DR: The results show that the acquisition of immortality is a crucial and rate-limiting step towards the establishment of a pluripotent state in somatic cells and underscore the similarities between induced pluripotency and tumorigenesis.
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A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
Jose M. Polo,Endre Anderssen,Endre Anderssen,Ryan M. Walsh,Benjamin A. Schwarz,Christian M. Nefzger,Sue Mei Lim,Marti Borkent,Marti Borkent,Effie Apostolou,Sara Alaei,Jennifer Cloutier,Ori Bar-Nur,Sihem Cheloufi,Matthias Stadtfeld,Maria E. Figueroa,Daisy A. Robinton,Sridaran Natesan,Ari Melnick,Jinfang Zhu,Sridhar Ramaswamy,Sridhar Ramaswamy,Konrad Hochedlinger,Konrad Hochedlinger +23 more
TL;DR: This integrative analysis allowed us to identify genes that act as roadblocks during reprogramming and surface markers that further enrich for cells prone to forming iPSCs, and offer new mechanistic insights into the nature and sequence of molecular events inherent to cellular reprograming.
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Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice
Katrin Arnold,Abby Sarkar,Abby Sarkar,Mary Anna Yram,Mary Anna Yram,Jose M. Polo,Jose M. Polo,Rod Bronson,Sumitra Sengupta,Marco Seandel,Niels Geijsen,Konrad Hochedlinger,Konrad Hochedlinger +12 more
TL;DR: It is shown that Sox2 marks adult cells in several epithelial tissues where its expression has not previously been characterized, including the stomach, cervix, anus, testes, lens, and multiple glands.
Journal ArticleDOI
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
Yuki Ohi,Han Qin,Chibo Hong,Laure Blouin,Jose M. Polo,Jose M. Polo,Tingxia Guo,Zhongxia Qi,Sara L. Downey,Philip D. Manos,Philip D. Manos,Derrick J. Rossi,Derrick J. Rossi,Jingwei Yu,Matthias Hebrok,Konrad Hochedlinger,Konrad Hochedlinger,Joseph F. Costello,Jun S. Song,Miguel Ramalho-Santos +19 more
TL;DR: In this article, a systematic comparison of human induced pluripotent stem (iPS) cells generated from hepatocytes (representative of endoderm), skin fibroblasts (mesoderm) and melanocytes (ectoderm).