E
Enza Lacivita
Researcher at University of Bari
Publications - 111
Citations - 2731
Enza Lacivita is an academic researcher from University of Bari. The author has contributed to research in topics: Receptor & Agonist. The author has an hindex of 30, co-authored 100 publications receiving 2327 citations. Previous affiliations of Enza Lacivita include Mario Negri Institute for Pharmacological Research.
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Journal ArticleDOI
Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders
TL;DR: Data on localization and pharmacological properties of the 5-HT(7) receptor is reviewed, and the results of structure-activity relationship studies aimed at the discovery of selective 5- HT( 7) receptor ligands are summarized.
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Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X syndrome.
Lara Costa,Michela Spatuzza,Simona D'Antoni,Carmela M. Bonaccorso,Chiara Trovato,Sebastiano A. Musumeci,Marcello Leopoldo,Enza Lacivita,Maria Vincenza Catania,Lucia Ciranna +9 more
TL;DR: Serotonin 7 receptor activation reverses metabotropic glutamate receptor-induced AMPA receptor internalization and LTD both in wild-type and in Fmr1 KO mice, correcting excessive mGluR-LTD.
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Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders.
TL;DR: This review focuses on possible cross talk between two serotonin receptors, 5‐ HT1A and the 5‐HT7, and the implication of heterodimerization in the development and maintenance of depression.
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Structure-affinity relationship study on N-[4-(4-arylpiperazin-1-yl)butyl]arylcarboxamides as potent and selective dopamine D3 receptor ligands
Marcello Leopoldo,Francesco Berardi,Nicola Antonio Colabufo,Paola De Giorgio,Enza Lacivita,Roberto Perrone,Vincenzo Tortorella +6 more
TL;DR: Several high-affinity D(3) ligands endowed with high selectivity over D(2), D(4), 5-HT(1A), and alpha(1) receptors are identified.
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5-HT1A receptor, an old target for new therapeutic agents.
TL;DR: The present review will focus on those 5 HT(1A) receptor agents that entered preclinical trials starting from 2000.