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Showing papers by "Erhard Haus published in 2004"


Journal ArticleDOI
TL;DR: The aims of the current study were to examine time-dependent cycles in the effect of topical CS application in healthy and irritated skin on skin blood flow and its relationship to barrier function and a significant correlation was found between skin temperature and skinBlood flow but not with TEWL.

63 citations


Journal ArticleDOI
TL;DR: The new study of time structures in biology with regard to influences from cosmo- helio- and geomagnetic rhythms chronoastrobiology is dubbed because it is emerging that rhythmic events generated from within the sun itself, as a large turbulent magnet in its own right, can have direct effects upon life on earth.

53 citations


Book ChapterDOI
TL;DR: Circadian rhythms centrally as well as peripherally also persist into old age, however, with changes in circadian mean and circadian amplitude, in general, in healthy subjects rhythmicity is maintained until very old age.
Abstract: The neuroendocrine systems shows in its central and peripheral components a time structure consisting of rhythms of multiple frequencies ranging from minutes (e.g. pulsatile secretions) and hours (ultradian rhythms) to the prominent about 24-hour (circadian) rhythms, and to lower (infradian) frequencies including seasonal variations or circannual rhythms. Optimal function of the human organism depends critically on the maintenance of these rhythms and their time relations among each other, and in some frequencies upon maintenance of environmental synchronization. The adrenal cortex shows with ageing a subtle increase in cortisol and more marked decrease in adrenal androgen production. The circadian amplitudes of some adrenal steroids decrease with ageing. The increase in cortisol with ageing was found to be correlated with cardiovascular pathology in the elderly. Age is the most important factor affecting circulating melatonin concentrations with significant decline in the elderly. This may lead to a loss in circadian time information and in antioxidant functions. Ageing changes in the hypothalamic-pituitary-thyroid axis show ethnic-geographic differences which in part may be due to environmental conditions (e.g. iodine supply). In prolactin secretion, circadian rhythmicity continues in the elderly. Catecholamine circadian rhythms centrally as well as peripherally also persist into old age, however, with changes in circadian mean and circadian amplitude. In general, in healthy subjects rhythmicity is maintained until very old age. However, some characteristic changes like, e.g., a decrease in the circadian amplitude of numerous variables, occur also in the clinically healthy elderly. With disease states developing with advancing age, circadian as well as rhythms in other frequencies may be markedly disturbed and the altered time structure may contribute to ill health and senility.

2 citations


Book ChapterDOI
01 Jan 2004
TL;DR: The development of the human circadian time structure as it pertains to the establishment of 24-h rhythms in BP, the management of childhood hypertension (HTN), and pediatric medicine is reviewed.
Abstract: About 24-h rhythms of systolic and diastolic blood pressure are an expression of numerous neural, endocrine, and vascular circadian rhythms superimposed on which are the differential day—night level of physical and emotional loads (1,2) The human circadian time structure begins to develop in utero It is completed in infants during the first 2 yr of life coinciding with the maturation of the neural, endocrine, and other systems The circadian clock, and the rhythms it generates, becomes fully entrained to the 24-h societal routine through daily exposure to cyclic environmental time cues, especially the alternation of light and darkness and the temporal pattern of childcare This article reviews the development of the human circadian time structure as it pertains to the establishment of 24-h rhythms in BP, the management of childhood hypertension (HTN), and pediatric medicine

1 citations