Showing papers in "Biomedicine & Pharmacotherapy in 2004"

TL;DR: Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds as discussed by the authors.

TL;DR: The role of mitochondria in apoptosis is crucial as discussed by the authors and its role is pivotal for modulation of critical cellular functions, notably for neurons astrocytes and microglia, such as apoptosis program activation, and ion transport, calcium mobilization, involved in excitotoxicity.

TL;DR: In this paper, the role of gap junctional communication between cells which may be a basis for protection against cancer development is independent of the antioxidant property of carotenoids, and increased intake of lycopene as the all-trans-isomer attenuates alcohol induced 2E1 cells and reduces risk of prostate, lung and digestive cancers.

TL;DR: The role of phosphorous in the immune response to disease and its role in disease progression is studied in molecular medicine and cell reprograming.

TL;DR: The goal of the present article is to review the advances made in the development and characterization of nanosystems intended to be used as drug carriers for mucosal administration, and to demonstrate the potential of these nanocarriers for overcoming important mucosal barriers.

TL;DR: The complementary relation between smoking and drinking can be understood at physiological, psychological and social levels, and the need for international agreement on alcohol as well as tobacco control is discussed.

TL;DR: In this paper, the most reliable serum marker for ovarian carcinoma, namely, CA 125, was found to correlate with the clinical course of disease better than other antigens, such as CA 19.9, CA 15.3 and TAG.

TL;DR: In this paper, a new method for measuring pulse wave velocity (PWV) has been proposed in Japan, where the brachial artery (ba) and the ankle was measured by applying air pressure with the aid of a volume plethysmograph.

TL;DR: In this article, the authors discuss the role of thiol imbalance in human pathologies, including homo-and cystinuria, homo and cysteinemia, and neural tube defects.

TL;DR: The cellular mechanisms impacted by combined smoking and alcohol exposure are poorly understood, but molecular epidemiology approaches are providing insights regarding the importance of effects on oxidant/antioxidant pathways and on metabolic pathways involving the cytochrome P450 system.

TL;DR: A literature review of the main studies on biomaterial biocompatibility and osteointegration both in vitro and in vivo in the presence of osteoporotic condition and the use of pathological bone-derived cells and pathological animals is recommended to test candidate orthopaedic materials.

TL;DR: In this article, a review of the mechanisms by which the common types of anticoagulants influence the primary tumor and metastatic processes of solid tumors is presented, focusing on the interference with proliferation of cancer cells, tumor angiogenesis, immunity system, cancer cell motility and adhesion.

TL;DR: The results from the latest in vivo studies show the capability of specific NFkappaB inhibitors in the clinical use and its potential as a target of pharmacological agents is summarized.

TL;DR: A strong association between elevated plasma low-density-lipoprotein (LDL) and the development of cardiovascular diseases (CVD) has been established in this article, where the authors showed that Ox-LDL enhances the production and release of tumor necrosis factor (TNF-α), interleukin (IL)-6, arachidonic acid metabolites and nitric oxide (NO) that are responsible for various human pathologies including cancer.

TL;DR: In this article, a spectral analysis of skin LD tracing shows an abnormal flowmotion, with increased amplitude of the flowmotion waves related to endothelial, neurogenic and myogenic activities, suggesting a relatively early skin microcirculatory adaptation in this PAOD stage.

TL;DR: The laboratory has focused on the use of hydrogel carriers to increase the bioavailability of orally administered therapeutic agents ranging from proteins such as insulin to chemotherapeutics like bleomycin.

TL;DR: It appears that for genetically Japanese people, environmental factors are important for the development of metabolic diseases such as diabetes mellitus and cardiovascular disease.

TL;DR: In this article, the effects of pravastatin treatment on the insulin resistance in patients with metabolic syndrome with impaired glucose tolerance (IGT), by Homeostasis Model Assessment (HOMA) test, insulin sensitivity indices and glucose half activation time (glucose t 1/2).

TL;DR: The potential of adjuvant hydrocarbon oils to induce autoimmunity has implications in the use of oil adjuvants in human and veterinary vaccines as well as basic research as discussed by the authors.

TL;DR: In this paper, the association between dementia and smoking or alcohol use has been examined in several epidemiological studies and it was shown that moderate consumption of wine was associated with a lower risk of developing Alzheimer's disease.

TL;DR: In this article, the effects of chronic sleep deprivation on autonomic activity by examining the heart rate variability, plasma catecholamine, and intracellular magnesium levels were determined from 24-hour ambulatory ECG monitoring, including time and frequency domain indices.

TL;DR: In this paper, the accuracy and predictive value of 18F-FDG PET in a large series of patients with rectal cancer treated with preoperative intensified chemo radiation therapy (CRT) was investigated.

TL;DR: Current evidence suggests that certain FcγR alleles are genetic risk factors for systemic autoimmune diseases and the development of major manifestations of these diseases, and genetic associations have been well documented in meta-analyses including a large number of studies.

TL;DR: Prolactin is not only a lactigenic hormone but also an immunomodulator involved in lymphocyte survival, activation and proliferation as mentioned in this paper, and there is increasing data implicating prolactin in autoimmunity, and specifically in SLE patients.

TL;DR: In this paper, the authors compared changes in anthropometric measures [body mass index (BMI), body weight] of obese patients treated with diet and exercise alone or additionally sibutramine, orlistat or the combination of both drugs, respectively.

TL;DR: In this paper, the authors examined the relationship between demographic, clinical and psychosocial variables and diabetes self-care management in Mexican type 2 diabetic patients and found that a good adherence to these three recommendations was observed in only 26.1% of the patients.

TL;DR: In this article, the level of DNA strand breaks as well as DNA repair processes using comet assay modifications was examined in children with Type 1 diabetes and their 1st degree relatives and confirmed increased oxidative stress in diabetic children.

TL;DR: In this article, the effects of piperine on ATPase enzymes were evaluated in lung cancer bearing mice, and it was shown that the beneficial effect was primarily exerted on the during initiation phase and post-initiation stage of B(a)p induced lung carcinogenesis.

TL;DR: In this paper, cyclophosphamide has been used to treat metastatic prostate cancer (MHRPC) for a long time, including estramustine, vinblastine, etoposide, taxanes and carboplatinum.

TL;DR: In this paper, a review of the physical and biological targeting of nucleic acid formulations into tumors and therapeutic approaches is presented, with a focus on the use of specific promotor/enhancer elements to restrict transcription of therapeutic genes to the target cells only.