Eric Chan

TL;DR: A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and inclusion bodies within an authentic cellular context, allowing assessment of the effects of protein aggregation directly in cells, without resorting to the use of non-physiological protein mutations or genetically engineered cell lines.

TL;DR: A novel method using the Cellometer image-based cytometry/fluorescent dye method in combination with Cyto-ID® Green dye for autophagy detection in live cells is developed and compared with flow cytometry by measuring macroautophagy in nutrient-starved Jurkat cells.

TL;DR: The results identify Contactin‐1 secreted by oligodendrocytes as a novel factor that may influence early steps of nodal sodium channel cluster formation along specific axon populations.

TL;DR: The cell binding data obtained for these solid cancer cell lines suggest that the sensitivity of a cell line to E1-Rap appears to correlate with its TROP-2 expression on the cell surface, which is 1,000- to 100,00-fold higher than untargeted Rap or the combination of Rap and hRS7.

TL;DR: Findings show that a CRISPR/Cas9-based therapy has the potential to upregulate HbF and treat diseases of b-globin and the long-term persistence of transplanted cells in a NOD-SCID-Gamma xeno-transplant mouse model is demonstrated.