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Brenda K. Eustace
Researcher at Vertex Pharmaceuticals
Publications - 30
Citations - 3755
Brenda K. Eustace is an academic researcher from Vertex Pharmaceuticals. The author has contributed to research in topics: Extracellular & Cancer cell. The author has an hindex of 18, co-authored 30 publications receiving 3244 citations. Previous affiliations of Brenda K. Eustace include University of Pennsylvania & Tufts University.
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Journal ArticleDOI
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.
Randall D. Little,John P. Carulli,Richard G. Del Mastro,Josée Dupuis,Mark Osborne,Colleen Folz,Susan P. Manning,Pamela Marie Swain,Shan Chuan Zhao,Brenda K. Eustace,Michelle M. Lappe,Lia Spitzer,Susan Zweier,Karen Braunschweiger,Youssef Benchekroun,Xintong Hu,Ronald Adair,Linda Chee,Michael Fitzgerald,Craig Tulig,Anthony Caruso,Nia Tzellas,Alicia Bawa,Barbara Franklin,Shannon M. McGuire,Shannon M. McGuire,Xavier Nogués,Xavier Nogués,Gordon Gong,Kristina Allen,Anthony Anisowicz,Arturo Morales,Peter T. Lomedico,Susan M. Recker,Paul Van Eerdewegh,Robert R. Recker,Mark L. Johnson +36 more
TL;DR: It is suggested that the HBM mutation confers a unique osteogenic activity in bone remodeling, and this understanding may facilitate the development of novel therapies for the treatment of osteoporosis.
Journal ArticleDOI
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness
Brenda K. Eustace,Takashi Sakurai,Takashi Sakurai,Jean K. Stewart,Dean Yimlamai,Christine Margarete Unger,Carol Zehetmeier,Blanca Lain,Claudia Torella,Stefan W. Henning,Gerald Beste,Bradley T. Scroggins,Len Neckers,Leodevico L. Ilag,Daniel G. Jay +14 more
TL;DR: Two functional screens for proteins required for the invasion of fibrosarcoma cells that identified the molecular chaperone heat shock protein 90 are described, indicating that cell-impermeant anti-hsp90 drugs might decrease invasiveness without the concerns inherent in inhibiting intracellular hsp90.
Journal ArticleDOI
CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia
Haydar Frangoul,David Altshuler,M. Domenica Cappellini,Yi-Shan Chen,Jennifer Domm,Brenda K. Eustace,Juergen Foell,la Fuente Josu de,Stephan A. Grupp,Rupert Handgretinger,Tony W. Ho,Antonis Kattamis,Andrew Kernytsky,Julie A. Lekstrom-Himes,Amanda M. Li,Franco Locatelli,Markus Y. Mapara,Montalembert Mariane de,Damiano Rondelli,Akshay Sharma,Sujit Sheth,Sandeep Soni,Martin H. Steinberg,Donna A. Wall,Angela Yen,Selim Corbacioglu +25 more
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CD155/PVR Plays a Key Role in Cell Motility During Tumor Cell Invasion and Migration
Kevin Ernest Sloan,Brenda K. Eustace,Jean K. Stewart,Carol Zehetmeier,Claudia Torella,Marina Simeone,Jennifer E. Roy,Christine Margarete Unger,David N. Louis,Leodevico L. Ilag,Daniel G. Jay +10 more
TL;DR: A functional proteomic screen has identified CD155 (the poliovirus receptor) as a mediator of tumor cell invasion through its role in migration and suggests that CD155 may contribute to tumorigenesis.
Journal ArticleDOI
CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia
Haydar Frangoul,David Altshuler,M. Domenica Cappellini,Yi-Shan Chen,Jennifer Domm,Brenda K. Eustace,Juergen Foell,Josu de la Fuente,Stephan A. Grupp,Rupert Handgretinger,Tony W. Ho,Antonis Kattamis,Andrew Kernytsky,Julie A. Lekstrom-Himes,Amanda M. Li,Franco Locatelli,Markus Y. Mapara,Mariane de Montalembert,Damiano Rondelli,Akshay Sharma,Sujit Sheth,Sandeep Soni,Martin H. Steinberg,Donna A. Wall,Angela Yen,Selim Corbacioglu +25 more
TL;DR: Electroporation of CD34+ hematopoietic stem and progenitor cells obtained from healthy donors was performed, with CRISPR-Cas9 targeting the BCL11A erythroid-specific enhancer, and approximately 80% of the alleles at this locus were modified, with no evidence of off-target editing.