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Eric R. Fearon

Researcher at University of Michigan

Publications -  183
Citations -  55140

Eric R. Fearon is an academic researcher from University of Michigan. The author has contributed to research in topics: Wnt signaling pathway & Gene. The author has an hindex of 84, co-authored 179 publications receiving 52910 citations. Previous affiliations of Eric R. Fearon include Johns Hopkins University School of Medicine & Johns Hopkins University.

Papers
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Journal ArticleDOI

Loss of estrogen receptor 1 enhances cervical cancer invasion.

Yali Zhai, +5 more
- 01 Aug 2010 - 
TL;DR: Findings indicate that loss of ESR1 has a major role in mediating cervical cancer invasion and progression, and molecular mechanisms underlying down-regulation of E SR1 in invasive cervical carcinomas appear to be complex and likely heterogeneous.
Patent

Detection of loss of the wild-type P53 gene and kits therefor

Bert Vogelstein, +3 more
TL;DR: In this article, both deletion mutations and point mutations in p53 are observed in the same human tumor cells and these mutations are clonal within the cells of the tumor, and loss of wild-type p53 genes is responsible for neoplastic progression.
Journal ArticleDOI

Rap1 Stabilizes β-catenin and Enhances β-catenin-dependent Transcription and Invasion in Squamous Cell Carcinoma of the Head and Neck

Mitsuo Goto, +10 more
- 01 Jan 2010 - 
TL;DR: The findings suggest that Rap1 enhances β-catenin stability and nuclear localization and highlight Rap1 as a potential therapeutic target in head and neck squamous cell carcinoma.
Journal ArticleDOI

Type I to Type II Ovarian Carcinoma Progression: Mutant Trp53 or Pik3ca Confers a More Aggressive Tumor Phenotype in a Mouse Model of Ovarian Cancer

Rong Wu, +5 more
- 01 Apr 2013 - 
TL;DR: The findings indicate that the adverse prognosis associated with TP53 and PIK3CA mutations in human cancers can be functionally replicated in mouse models of type I→type II OvCA progression and should represent a robust platform for assessment of the contributions of Trp53 or Pik3ca defects in the response of EOCs to conventional and targeted drugs.
Journal ArticleDOI

DRO1, a Gene Down-regulated by Oncogenes, Mediates Growth Inhibition in Colon and Pancreatic Cancer Cells

Guido T. Bommer, +12 more
- 04 Mar 2005 - 
TL;DR: The predicted DRO1 protein contains three repetitive elements with significant similarity to the carboxyl-terminal regions of the predicted proteins from DRS/SRPX/ETX1 and SRPUL genes, suggesting the existence of a new protein family.