Eric R. Fearon

TL;DR: In this paper, both deletion mutations and point mutations in p53 are observed in the same human tumor cells and these mutations are clonal within the cells of the tumor, and loss of wild-type p53 genes is responsible for neoplastic progression.

TL;DR: Findings implicate SHARP as an important positive regulator of Wnt signaling in cancers with beta-catenin dysregulation.

TL;DR: CDX2 is probably important for basal expression of MDR1, regulating drug excretion and absorption in the lower gastrointestinal tract, as well as for multidrug resistance to chemotherapy reagent in CDX2-positive gastrointestinal cancers.

TL;DR: In insights into the role of tankyrase in regulating the Wnt/beta-catenin pathway, it is suggested that compounds targeting tankyr enzyme's poly-ADP-ribosylation (PARsylation) activity may hold promise for cancer therapy.

TL;DR: It is unlikely that common CDX2 variants account for a measurable fraction of susceptibility to colorectal cancer in this population, butCDX2 expression levels were strongly associated with microsatellite instability and tumor location in the gastrointestinal tract, consistent with a possible role in the specification of gastrointestinal epithelial cell fate in humans.