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Benjamin M. Chain
Researcher at University College London
Publications - 235
Citations - 10066
Benjamin M. Chain is an academic researcher from University College London. The author has contributed to research in topics: T cell & Immune system. The author has an hindex of 50, co-authored 226 publications receiving 8553 citations. Previous affiliations of Benjamin M. Chain include Jagiellonian University Medical College & Imperial College London.
Papers
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Journal ArticleDOI
The sequence of sequencers: The history of sequencing DNA.
TL;DR: This article traverses those years, iterating through the different generations of sequencing technology, highlighting some of the key discoveries, researchers, and sequences along the way.
Journal ArticleDOI
Hypochlorous Acid: A Natural Adjuvant That Facilitates Antigen Processing, Cross-Priming, and the Induction of Adaptive Immunity
Zofia Prokopowicz,Frederick Arce,Rafał Biedroń,Cheryl Lai-Lai Chiang,Marta Ciszek,David R. Katz,Maria Nowakowska,Szczepan Zapotoczny,Janusz Marcinkiewicz,Benjamin M. Chain +9 more
TL;DR: It is shown that, in addition to its well-established role as a microbicide, HOCl can act as a natural adjuvant of adaptive immunity, suggesting novel strategies to enhance immunity to vaccines.
Journal ArticleDOI
Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose.
Catherine J. Reynolds,Corinna Pade,Joseph M Gibbons,David Butler,Ashley Otter,Katia Menacho,Marianna Fontana,Marianna Fontana,Angelique Smit,Jane E. Sackville-West,Teresa Cutino-Moguel,Mala K. Maini,Benjamin M. Chain,Mahdad Noursadeghi,Tim Brooks,Amanda Semper,Charlotte Manisty,Charlotte Manisty,Thomas A. Treibel,Thomas A. Treibel,James C. Moon,James C. Moon,UK COVIDsortium Investigators,Ana M. Valdes,Ana M. Valdes,Áine McKnight,Daniel M. Altmann,Rosemary J. Boyton +27 more
TL;DR: In this paper, the authors investigated if single dose vaccination, with or without prior infection, confers cross-protective immunity to variants of SARS-CoV-2 vaccine rollout has coincided with the spread of variants of concern.
Journal ArticleDOI
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.
Leo Swadling,Mariana O. Diniz,Nathalie M. Schmidt,Oliver E. Amin,Aneesh Chandran,Emily Shaw,Corinna Pade,Joseph M Gibbons,Nina Le Bert,Anthony T. Tan,Anna Jeffery-Smith,Anna Jeffery-Smith,Cedric C.S. Tan,Christine Y.L. Tham,Stephanie Kucykowicz,Gloryanne Aidoo-Micah,Joshua Rosenheim,Jessica Davies,Marina Johnson,Melanie P. Jensen,Melanie P. Jensen,George Joy,George Joy,Laura E. McCoy,Ana M. Valdes,Ana M. Valdes,Benjamin M. Chain,David Goldblatt,Daniel M. Altmann,Rosemary J. Boyton,Rosemary J. Boyton,Charlotte Manisty,Charlotte Manisty,Thomas A. Treibel,Thomas A. Treibel,James C. Moon,James C. Moon,Lucy van Dorp,Francois Balloux,Áine McKnight,Mahdad Noursadeghi,Antonio Bertoletti,Antonio Bertoletti,Mala K. Maini +43 more
TL;DR: In this paper, the authors measured SARS-CoV-2-reactive T-cells, including those against the early transcribed replication transcription complex (RTC) in intensively monitored healthcare workers (HCW), remaining repeatedly negative by PCR, antibody binding, and neutralization (seronegative HCW, SN-HCW).
Journal ArticleDOI
Antigen processing for presentation by class II major histocompatibility complex requires cleavage by cathepsin E.
TL;DR: Functional studies using a highly specific inhibitor of cathepsin E show that this enzyme is essential for the processing of ovalbumin by this cell line, indicating that cathePSin E, whose function was hitherto unknown, may play a major role in antigen processing.