D
David N. Nguyen
Researcher at University of California, San Francisco
Publications - 36
Citations - 4110
David N. Nguyen is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Genome editing & Immune system. The author has an hindex of 20, co-authored 33 publications receiving 3150 citations. Previous affiliations of David N. Nguyen include University of California, Berkeley & Harvard University.
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Journal ArticleDOI
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akin Akinc,Andreas Zumbuehl,Andreas Zumbuehl,Michael S. Goldberg,Elizaveta S. Leshchiner,Valentina Busini,Naushad Hossain,Sergio Bacallado,David N. Nguyen,Jason Fuller,Rene Alvarez,Anna Borodovsky,Todd Borland,Rainer Constien,Antonin de Fougerolles,J. Robert Dorkin,K. Narayanannair Jayaprakash,Muthusamy Jayaraman,Matthias John,Victor Koteliansky,Muthiah Manoharan,Lubomir Nechev,June Qin,Timothy Racie,Denitza Raitcheva,Kallanthottathil G. Rajeev,Dinah W.Y. Sah,Jürgen Soutschek,Ivanka Toudjarska,Hans-Peter Vornlocher,Tracy Zimmermann,Robert Langer,Daniel G. Anderson +32 more
TL;DR: A new class of lipid-like delivery molecules, termed lipidoids, are described, that facilitate high levels of specific silencing of endogenous gene transcripts when formulated with either double-stranded small interfering RNA (siRNA) or single-Stranded antisense 2′-O-methyl (2′-OMe) oligoribonucleotides targeting microRNA (miRNA).
Journal ArticleDOI
Reprogramming human T cell function and specificity with non-viral genome targeting
Theodore L. Roth,Cristina Puig-Saus,Ruby Yu,Ruby Yu,Eric Shifrut,Eric Shifrut,Julia Carnevale,P. Jonathan Li,P. Jonathan Li,Joseph Hiatt,Justin Saco,Paige Krystofinski,Han Li,Victoria Tobin,Victoria Tobin,David N. Nguyen,David N. Nguyen,Michael R. Lee,Amy L. Putnam,Andrea L. Ferris,Jeff W. Chen,Jean Nicolas Schickel,Laurence Pellerin,David Carmody,Gorka Alkorta-Aranburu,Daniela del Gaudio,Hiroyuki Matsumoto,Montse Morell,Ying Mao,Min Cho,Rolen M. Quadros,Channabasavaiah B. Gurumurthy,Baz Smith,Michael Haugwitz,Stephen H. Hughes,Jonathan S. Weissman,Kathrin Schumann,Kathrin Schumann,Jonathan H. Esensten,Andrew P. May,Alan Ashworth,Gary M. Kupfer,Siri Atma W. Greeley,Rosa Bacchetta,Eric Meffre,Maria Grazia Roncarolo,Neil Romberg,Neil Romberg,Kevan C. Herold,Antoni Ribas,Manuel D. Leonetti,Alexander Marson +51 more
TL;DR: A non-viral strategy to introduce large DNA sequences into T cells enables the correction of a pathogenic mutation that causes autoimmunity, and the replacement of an endogenous T-cell receptor with an engineered receptor that can recognize cancer antigens.
Journal ArticleDOI
Polymeric Materials for Gene Delivery and DNA Vaccination.
TL;DR: This Review focuses on the recent progress and challenges facing materials design for nonviral DNA vaccine drug delivery systems, and highlights work on new polymeric materials and their effects on protective immune activation, gene delivery, and current efforts to optimize polymeric delivery systems for DNA vaccination.
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Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines.
Chun Wang,Qing Ge,David T. Ting,David T. Ting,David N. Nguyen,David N. Nguyen,Hui Rong Shen,Jianzhu Chen,Herman N. Eisen,Jorge Heller,Robert Langer,David Putnam,David Putnam +12 more
TL;DR: The design of synthetic biodegradable polymers specifically for enhancing DNA vaccine efficacy in vivo are molecularly engineered poly(ortho ester) microspheres that are non-toxic to cells, protect DNA from degradation, enable uptake by antigen-presenting cells, and release DNA rapidly in response to phagosomal pH.
Journal ArticleDOI
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance.
Jeffrey D. Whitman,Joseph Hiatt,Cody T. Mowery,Brian R. Shy,Ruby Yu,Tori N. Yamamoto,Ujjwal Rathore,Gregory M. Goldgof,Caroline Whitty,Jonathan M. Woo,Jonathan M. Woo,Antonia E. Gallman,Tyler E. Miller,Andrew G. Levine,David N. Nguyen,David N. Nguyen,Sagar P. Bapat,Joanna Balcerek,Sophia A. Bylsma,Ana M. Lyons,Stacy Li,Allison W. Wong,Eva M. Gillis-Buck,Zachary Steinhart,Youjin Lee,Ryan Apathy,Ryan Apathy,Mitchell J. Lipke,Jennifer A Smith,Tina Zheng,Ian C. Boothby,Erin Isaza,Jackie Chan,Dante D. Acenas,Jinwoo Lee,Trisha A. Macrae,Than S. Kyaw,David Wu,Dianna Ng,Wei Gu,Vanessa A. York,Haig A. Eskandarian,Perri C. Callaway,Perri C. Callaway,Lakshmi Warrier,Mary E. Moreno,Justine Levan,Leonel Torres,Lila A. Farrington,Rita P. Loudermilk,Kanishka Koshal,Kelsey C. Zorn,Wilfredo F. Garcia-Beltran,Diane Yang,Michael G Astudillo,Bradley E. Bernstein,Jeffrey A. Gelfand,Edward T. Ryan,Richelle C. Charles,A. John Iafrate,Jochen K. Lennerz,Steve Miller,Charles Y. Chiu,Susan L. Stramer,Michael R. Wilson,Aashish Manglik,Chun Jimmie Ye,Nevan J. Krogan,Nevan J. Krogan,Mark S. Anderson,Jason G. Cyster,Joel D. Ernst,Alan H.B. Wu,Kara L. Lynch,Caryn Bern,Patrick D. Hsu,Alexander Marson +76 more
TL;DR: A head-to-head evaluation of ten point-of-care-style lateral flow assays and two laboratory-based enzyme-linked immunosorbent assays to detect anti-SARS-CoV-2 IgM and IgG antibodies in 5-d time intervals from symptom onset underline the importance of seropositivity threshold determination and reader training for reliable LFA deployment.