Erida Gjini

TL;DR: This work compares aggressive and moderate antibiotic treatment, accounting for host immunity effects, and explains key parameters and dimensions, where an adaptive regime differs from classical treatment, bringing new insight into the ongoing debate of resistance management.

TL;DR: It is demonstrated that the establishment of disease tolerance to malaria relies on a tissue damage-control mechanism that operates specifically in renal proximal tubule epithelial cells (RPTEC), which relies on the induction of heme oxygenase-1 and ferritin H chain via a mechanism that involves the transcription-factor nuclear-factor E2-related factor-2 (NRF2).

TL;DR: A mechanistic framework for modeling within‐host infection dynamics of the sleeping sickness parasite, the African trypanosome, shows that the degree of synchronization in stochastic variant emergence determines the relative dominance of general over specific control within a single peak.

TL;DR: An integrated modeling framework for understanding strain coexistence in polymorphic pathogen systems is described, conveying that direct competition for colonization mediates stable coexistence only when competitive abilities amongst pathogen clones satisfy certain pairwise asymmetries.

TL;DR: A method is introduced to assess host susceptibility to pathogens, and applied to a detailed dataset generated by challenging groups of insect hosts with a range of pathogen doses and recording survival over time, which provides novel insights for study design and analyses to assess interventions.