Sofia Rebelo

TL;DR: Sickle human hemoglobin confers a survival advantage to individuals living in endemic areas of malaria, the disease caused by Plasmodium infection, as demonstrated hereby, mice expressing sickle Hb do not succumb to experimental cerebral malaria (ECM).

TL;DR: Findings indicate a novel interplay between Hippo pathway activity and actin filament dynamics that is essential for normal growth control.

TL;DR: A mechanism of host defense against Plasmodium infection is described, based on tissue cytoprotection against free heme and limiting disease severity irrespectively of parasite burden.

TL;DR: It is demonstrated that induction of the iron-sequestering ferritin H chain in response to polymicrobial infections is critical to establish disease tolerance to sepsis and a crosstalk between adaptive responses controlling iron and glucose metabolism is required to maintain blood glucose within a physiologic range compatible with host survival.

TL;DR: It is reported that expression of heme oxygenase-1 (HO-1, encoded by Hmox1) is upregulated in the liver following infection by Plasmodium berghei and PlasModium yoelii sporozoites, which modulates the host inflammatory response, protecting the infected hepatocytes and promoting the liver stage of infection.