E
Erik Van Herck
Researcher at Katholieke Universiteit Leuven
Publications - 33
Citations - 2436
Erik Van Herck is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Insulin & Bone remodeling. The author has an hindex of 18, co-authored 33 publications receiving 2340 citations. Previous affiliations of Erik Van Herck include Catholic University of Leuven.
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Journal ArticleDOI
Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects.
Sophie Van Cromphaut,Mieke Dewerchin,Joost G. J. Hoenderop,Ingrid Stockmans,Erik Van Herck,Shigeaki Kato,René J. M. Bindels,Desire Collen,Peter Carmeliet,Roger Bouillon,Geert Carmeliet +10 more
Abstract: Rickets and hyperparathyroidism caused by a defective vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)2 vitamin D [1,25(OH)2D3] action on calcium homeostasis. We assessed the rate of serum 45Ca accumulation within 10 min of oral gavage in two strains of VDR-knockout (KO) mice (Leuven and Tokyo KO) and observed a 3-fold lower area under the curve in both KO strains. Moreover, we evaluated the expression of intestinal candidate genes involved in transcellular calcium transport. The calcium transport protein1 (CaT1) was more abundantly expressed at mRNA level than the epithelial calcium channel (ECaC) in duodenum, but both were considerably reduced (CaT1>90%, ECaC>60%) in the two VDR-KO strains on a normal calcium diet. Calbindin-D9K expression was decreased only in the Tokyo KO, whereas plasma membrane calcium ATPase (PMCA1b) expression was normal in both VDR-KOs. In Leuven wild-type mice, a high calcium diet inhibited (>90%) and 1,25(OH)2D3 injection or low calcium diet induced (6-fold) duodenal CaT1 expression and, to a lesser degree, ECaC and calbindin-D9K expression. In Leuven KO mice, however, high or low calcium intake decreased calbindin-D9K and PMCA1b expression, whereas CaT1 and ECaC expression remained consistently low on any diet. These results suggest that the expression of the novel duodenal epithelial calcium channels (in particular CaT1) is strongly vitamin D-dependent, and that calcium influx, probably interacting with calbindin-D9K, should be considered as a rate-limiting step in the process of vitamin D-dependent active calcium absorption.
Journal Article
Duodenal calcium absorption in vitamin D receptor-knock out mice: functional and molecular aspects
Sophie Van Cromphaut,Mieke Dewerchin,Jgj Hoenderop,Ingrid Stockmans,Erik Van Herck,Shigeaki Kato,Rjm Bindels,Desire Collen,Peter Carmeliet,Roger Bouillon,Geert Carmeliet +10 more
TL;DR: The results suggest that the expression of the novel duodenal epithelial calcium channels (in particular CaT1) is strongly vitamin D-dependent, and that calcium influx, probably interacting with calbindin-D9K, should be considered as a rate-limiting step in the process of vitamin D -dependent active calcium absorption.
Journal ArticleDOI
Metabolic, Endocrine, and Immune Effects of Stress Hyperglycemia in a Rabbit Model of Prolonged Critical Illness
Frank Weekers,Annapaula Giulietti,Marina Michalaki,Willy Coopmans,Erik Van Herck,Chantal Mathieu,Greet Van den Berghe +6 more
TL;DR: Investigation of the effect of blood glucose control with insulin on endocrine, metabolic, and immune function in an animal model of severe injury found maintenance of normoglycemia with exogenous insulin after severe trauma to a large extent prevented weight loss, lactic acidosis, and hyponatremia.
Journal ArticleDOI
C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight
Johan Verhaeghe,Rita van Bree,Erik Van Herck,Jozef Laureys,Roger Bouillon,F. André Van Assche +5 more
TL;DR: Insulin, insulin- like growth factors I and II and insulin are all related to fetal growth and weight gain, and insulin-like growth factor-I correlates best with birth weight.
Journal ArticleDOI
Hypogonadism, quadriceps weakness, and exercise intolerance in chronic obstructive pulmonary disease.
Monique van Vliet,Martijn A. Spruit,Geert Verleden,Ahmad Kasran,Erik Van Herck,Fabio Pitta,Roger Bouillon,Marc Decramer +7 more
TL;DR: In contrast to exercise intolerance, quadriceps muscle weakness is related to low circulating levels of testosterone in men with COPD.