E
Ernest C. Madu
Researcher at University of Tennessee Health Science Center
Publications - 55
Citations - 1580
Ernest C. Madu is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Population & Coronary artery disease. The author has an hindex of 16, co-authored 53 publications receiving 1461 citations. Previous affiliations of Ernest C. Madu include University of Toledo Medical Center & University of Florida.
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Journal ArticleDOI
Calmodulin kinase II inhibition protects against structural heart disease
Rong Zhang,Michelle S.C. Khoo,Yuejin Wu,Yingbo Yang,Chad E. Grueter,Gemin Ni,Edward Price,William H. Thiel,Silvia Guatimosim,Silvia Guatimosim,Long-Sheng Song,Ernest C. Madu,Anisha N Shah,Tatiana A. Vishnivetskaya,James B. Atkinson,Vsevolod V. Gurevich,Guy Salama,W. J. Lederer,Roger J. Colbran,Mark E. Anderson +19 more
TL;DR: CaMKII inhibition substantially prevented maladaptive remodeling from excessive βAR stimulation and myocardial infarction, and induced balanced changes in excitation-contraction coupling that preserved baseline and βAR-stimulated physiological increases in cardiac function.
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Cardiovascular Complications of Cocaine
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Death, Cardiac Dysfunction, and Arrhythmias Are Increased by Calmodulin Kinase II in Calcineurin Cardiomyopathy
Michelle S.C. Khoo,Jingdong Li,Jingdong Li,Madhu V. Singh,Yingbo Yang,Prince J. Kannankeril,Yuejin Wu,Chad E. Grueter,Xiaoqun Guan,Carmine V. Oddis,Rong Zhang,Lisa A. Mendes,Gemin Ni,Ernest C. Madu,Jinying Yang,Martha A. Bass,Rey J. Gomez,Brian E. Wadzinski,Eric N. Olson,Roger J. Colbran,Mark E. Anderson +20 more
TL;DR: CaMKII is a downstream signal in CAN cardiomyopathy, and increased CaMKII activity contributes to cardiac dysfunction, arrhythmia susceptibility, and longevity during CAN overexpression.
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Temporal changes in ventricular function assessed echocardiographically in conscious and anesthetized mice.
Jeffrey N. Rottman,Gemin Ni,Michelle S.C. Khoo,Zhizhang Wang,Wei Zhang,Mark E. Anderson,Ernest C. Madu +6 more
TL;DR: Serial echocardiographic assessments of cardiac function, dimension, and mass can be performed with high reproducibility in conscious mice, and the relationship between heart rate and fractional shortening was not altered by anesthetic choice.
Journal ArticleDOI
Fluoxetine hydrochloride for the treatment of severe refractory orthostatic hypotension
Blair P. Grubb,Daniela Samoil,Daniel Kosinski,Douglas A. Wolfe,Michael Lorton,Ernest C. Madu +5 more
TL;DR: Fluoxetine hydrochloride may be an effective therapy for some patients with recurrent severe orthostatic hypotension refractory to other forms of therapy.