J
Jingdong Li
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 18
Citations - 1413
Jingdong Li is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Ca2+/calmodulin-dependent protein kinase & Phospholamban. The author has an hindex of 13, co-authored 16 publications receiving 1240 citations. Previous affiliations of Jingdong Li include Johns Hopkins University School of Medicine & Huazhong University of Science and Technology.
Papers
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Journal ArticleDOI
CaMKII determines mitochondrial stress responses in heart
Mei Ling A. Joiner,Olha M. Koval,Jingdong Li,Jingdong Li,B. Julie He,Chantal Allamargot,Zhan Gao,Elizabeth D. Luczak,Duane D. Hall,Brian D. Fink,Biyi Chen,Jinying Yang,Steven A. Moore,Thomas D. Scholz,Stefan Strack,Peter J. Mohler,Peter J. Mohler,William I. Sivitz,William I. Sivitz,Long-Sheng Song,Mark E. Anderson +20 more
TL;DR: CaMKII activity is identified as a central mechanism for mitochondrial Ca2+ entry in myocardial cell death, and indicates that mitochondrial-targeted CaMKII inhibition could prevent or reduce myocardials death and heart failure in response to common experimental forms of pathophysiological stress.
Journal ArticleDOI
A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice
Thomas J. Hund,Olha M. Koval,Jingdong Li,Patrick J. Wright,Lan Qian,Jedidiah S. Snyder,Hjalti Gudmundsson,Crystal F. Kline,Nathan Paul Davidson,Natalia Cardona,Matthew N. Rasband,Mark E. Anderson,Peter J. Mohler +12 more
TL;DR: In this paper, the authors identified β(IV)-spectrin as a multifunctional regulatory platform for voltage-gated Na(+) channels in mice, and found that β(4)-Spectrin targeted critical structural and regulatory proteins to excitable membranes in the heart and brain.
Journal ArticleDOI
Phosphorylation of the ryanodine receptor mediates the cardiac fight or flight response in mice.
Jian Shan,Alexander Kushnir,Matthew J. Betzenhauser,Steven Reiken,Jingdong Li,Stephan E. Lehnart,Nicolas Lindegger,Marco Mongillo,Peter J. Mohler,Andrew R. Marks +9 more
TL;DR: These studies identify what they believe to be new roles for PKA phosphorylation of RyR2 in both the heart rate and contractile responses to acute catecholaminergic stimulation.
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Death, Cardiac Dysfunction, and Arrhythmias Are Increased by Calmodulin Kinase II in Calcineurin Cardiomyopathy
Michelle S.C. Khoo,Jingdong Li,Jingdong Li,Madhu V. Singh,Yingbo Yang,Prince J. Kannankeril,Yuejin Wu,Chad E. Grueter,Xiaoqun Guan,Carmine V. Oddis,Rong Zhang,Lisa A. Mendes,Gemin Ni,Ernest C. Madu,Jinying Yang,Martha A. Bass,Rey J. Gomez,Brian E. Wadzinski,Eric N. Olson,Roger J. Colbran,Mark E. Anderson +20 more
TL;DR: CaMKII is a downstream signal in CAN cardiomyopathy, and increased CaMKII activity contributes to cardiac dysfunction, arrhythmia susceptibility, and longevity during CAN overexpression.
Journal ArticleDOI
Defects in Ankyrin-Based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation
Shane R. Cunha,Shane R. Cunha,Thomas J. Hund,Seyed Hashemi,Niels Voigt,Na Li,Patrick Wright,Olha M. Koval,Jingdong Li,Hjalti Gudmundsson,Richard J. Gumina,Matthias Karck,Jean-Jacques Schott,Vincent Probst,Hervé Le Marec,Mark E. Anderson,Dobromir Dobrev,Xander H.T. Wehrens,Peter J. Mohler +18 more
TL;DR: Findings support that reduced ankyrin-B expression or mutations in ANK2 are associated with AF, and demonstrate a novel pathway for ankyrIn-B–dependent regulation of Cav1.3 channel membrane targeting and regulation in atrial myocytes.