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Xiaoqun Guan
Researcher at University of Iowa
Publications - 15
Citations - 2200
Xiaoqun Guan is an academic researcher from University of Iowa. The author has contributed to research in topics: Ca2+/calmodulin-dependent protein kinase & Angiotensin II. The author has an hindex of 11, co-authored 13 publications receiving 1961 citations. Previous affiliations of Xiaoqun Guan include Roy J. and Lucille A. Carver College of Medicine.
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Journal ArticleDOI
A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation
Jeffrey R. Erickson,Mei Ling A. Joiner,Xiaoqun Guan,William Kutschke,Jinying Yang,Carmine V. Oddis,Ryan K. Bartlett,John S. Lowe,Susan E. O'Donnell,Nukhet Aykin-Burns,Matthew C. Zimmerman,Kathy Zimmerman,Amy-Joan L. Ham,Robert M. Weiss,Douglas R. Spitz,Madeline A. Shea,Roger J. Colbran,Peter J. Mohler,Mark E. Anderson +18 more
TL;DR: It is shown that oxidation of paired regulatory domain methionine residues sustains CaMKII activity in the absence of Ca2+/CaM and highlights the critical importance of oxidation-dependent CaMK II activation to AngII and ischemic myocardial apoptosis.
Journal ArticleDOI
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.
Anil Purohit,Adam G. Rokita,Xiaoqun Guan,Biyi Chen,Olha M. Koval,Niels Voigt,Niels Voigt,Stefan Neef,Thomas Sowa,Zhan Gao,Elizabeth D. Luczak,Hrafnhildur Stefansdottir,Andrew C. Behunin,Na Li,Ramzi N. El-Accaoui,Baoli Yang,Paari Dominic Swaminathan,Robert M. Weiss,Xander H.T. Wehrens,Long-Sheng Song,Dobromir Dobrev,Dobromir Dobrev,Lars S. Maier,Mark E. Anderson,Mark E. Anderson +24 more
TL;DR: CaMKII is a molecular signal that couples increased reactive oxygen species with AF and that therapeutic strategies to decrease oxidized CaMKII may prevent or reduce AF.
Journal ArticleDOI
Oxidation of CaMKII determines the cardiotoxic effects of aldosterone
B. Julie He,Mei Ling A. Joiner,Madhu V. Singh,Elizabeth D. Luczak,Paari Dominic Swaminathan,Olha M. Koval,William J. Kutschke,Chantal Allamargot,Jinying Yang,Xiaoqun Guan,Kathy Zimmerman,Isabella M. Grumbach,Robert M. Weiss,Douglas R. Spitz,Curt D. Sigmund,W. Matthijs Blankesteijn,Stephane Heymans,Stephane Heymans,Peter J. Mohler,Mark E. Anderson +19 more
TL;DR: It is shown that oxidized myocardial CaMKII mediates the cardiotoxic effects of aldosterone on the cardiac matrix and establish CaMK II as a nodal signal for the neurohumoral pathways associated with poor outcomes after myocardia infarction.
Journal ArticleDOI
Diabetes increases mortality after myocardial infarction by oxidizing CaMKII.
Min Luo,Xiaoqun Guan,Elizabeth D. Luczak,Di Lang,William Kutschke,Zhan Gao,Jinying Yang,Patric Glynn,Samuel Sossalla,Paari Dominic Swaminathan,Robert M. Weiss,Baoli Yang,Adam G. Rokita,Adam G. Rokita,Lars S. Maier,Igor R. Efimov,Thomas J. Hund,Mark E. Anderson +17 more
TL;DR: The findings suggest that activation of a mitochondrial/ox-CaMKII pathway contributes to increased sudden death in diabetic patients after myocardial infarction.
Journal ArticleDOI
Calmodulin kinase II is required for fight or flight sinoatrial node physiology.
Yuejin Wu,Zhan Gao,Biyi Chen,Olha M. Koval,Madhu V. Singh,Xiaoqun Guan,Thomas J. Hund,William Kutschke,Satyam Sarma,Isabella M. Grumbach,Xander H.T. Wehrens,Peter J. Mohler,Long-Sheng Song,Mark E. Anderson,Mark E. Anderson +14 more
TL;DR: The tightly coupled, but previously unanticipated, relationship of CaMKII to the βAR pathway in fight or flight physiology is shown andCaMKII is established as a critical signaling molecule for physiological HR responses to catecholamines.