M
Michelle S.C. Khoo
Researcher at Vanderbilt University
Publications - 9
Citations - 885
Michelle S.C. Khoo is an academic researcher from Vanderbilt University. The author has contributed to research in topics: Ca2+/calmodulin-dependent protein kinase & Calcineurin. The author has an hindex of 5, co-authored 9 publications receiving 835 citations. Previous affiliations of Michelle S.C. Khoo include University of Colorado Denver & Vanderbilt University Medical Center.
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Journal ArticleDOI
Calmodulin kinase II inhibition protects against structural heart disease
Rong Zhang,Michelle S.C. Khoo,Yuejin Wu,Yingbo Yang,Chad E. Grueter,Gemin Ni,Edward Price,William H. Thiel,Silvia Guatimosim,Silvia Guatimosim,Long-Sheng Song,Ernest C. Madu,Anisha N Shah,Tatiana A. Vishnivetskaya,James B. Atkinson,Vsevolod V. Gurevich,Guy Salama,W. J. Lederer,Roger J. Colbran,Mark E. Anderson +19 more
TL;DR: CaMKII inhibition substantially prevented maladaptive remodeling from excessive βAR stimulation and myocardial infarction, and induced balanced changes in excitation-contraction coupling that preserved baseline and βAR-stimulated physiological increases in cardiac function.
Journal ArticleDOI
Death, Cardiac Dysfunction, and Arrhythmias Are Increased by Calmodulin Kinase II in Calcineurin Cardiomyopathy
Michelle S.C. Khoo,Jingdong Li,Jingdong Li,Madhu V. Singh,Yingbo Yang,Prince J. Kannankeril,Yuejin Wu,Chad E. Grueter,Xiaoqun Guan,Carmine V. Oddis,Rong Zhang,Lisa A. Mendes,Gemin Ni,Ernest C. Madu,Jinying Yang,Martha A. Bass,Rey J. Gomez,Brian E. Wadzinski,Eric N. Olson,Roger J. Colbran,Mark E. Anderson +20 more
TL;DR: CaMKII is a downstream signal in CAN cardiomyopathy, and increased CaMKII activity contributes to cardiac dysfunction, arrhythmia susceptibility, and longevity during CAN overexpression.
Journal ArticleDOI
Temporal changes in ventricular function assessed echocardiographically in conscious and anesthetized mice.
Jeffrey N. Rottman,Gemin Ni,Michelle S.C. Khoo,Zhizhang Wang,Wei Zhang,Mark E. Anderson,Ernest C. Madu +6 more
TL;DR: Serial echocardiographic assessments of cardiac function, dimension, and mass can be performed with high reproducibility in conscious mice, and the relationship between heart rate and fractional shortening was not altered by anesthetic choice.
Journal ArticleDOI
Calmodulin Inhibitor W-7 Unmasks a Novel Electrocardiographic Parameter That Predicts Initiation of Torsade de Pointes
T. David Gbadebo,Robert W. Trimble,Michelle S.C. Khoo,Joel Temple,Dan M. Roden,Mark E. Anderson +5 more
TL;DR: Findings are consistent with the idea that prolonged repolarization is not the proximate cause of arrhythmia initiation, and they suggest that an increased UTA ratio reflects activation of intracellular Ca2+/calmodulin–dependent processes that are required for triggering TdP in this model.
Journal ArticleDOI
Calmodulin kinase II activity is required for normal atrioventricular nodal conduction.
Michelle S.C. Khoo,Prince J. Kannankeril,Jingdong Li,Rong Zhang,Sabina Kupershmidt,Wei Zhang,James B. Atkinson,Roger J. Colbran,Dan M. Roden,Mark E. Anderson +9 more
TL;DR: These studies define CaMKII as a critical determinant of normal and catecholamine-stimulated AV nodal conduction responses.