E
Ernest D. Laue
Researcher at University of Cambridge
Publications - 146
Citations - 15190
Ernest D. Laue is an academic researcher from University of Cambridge. The author has contributed to research in topics: Chromatin & Protein structure. The author has an hindex of 56, co-authored 145 publications receiving 13907 citations. Previous affiliations of Ernest D. Laue include Lankenau Institute for Medical Research.
Papers
More filters
Journal ArticleDOI
The CCPN data model for NMR spectroscopy: Development of a software pipeline
Wim F. Vranken,Wayne Boucher,Tim J. Stevens,Rasmus H. Fogh,Anne Pajon,Miguel Llinás,Eldon L. Ulrich,John L. Markley,John Ionides,Ernest D. Laue +9 more
TL;DR: The development of a set of software applications that use the Data Model and its associated libraries, thus validating the approach and providing a pipeline for high‐throughput analysis of NMR data.
Journal ArticleDOI
Single-cell Hi-C reveals cell-to-cell variability in chromosome structure
Takashi Nagano,Yaniv Lubling,Tim J. Stevens,Stefan Schoenfelder,Eitan Yaffe,Wendy Dean,Ernest D. Laue,Amos Tanay,Peter Fraser +8 more
TL;DR: Single-cell Hi-C data bridge current gaps between genomics and microscopy studies of chromosomes, demonstrating how modular organization underlies dynamic chromosome structure, and how this structure is probabilistically linked with genome activity patterns.
Journal ArticleDOI
3D structures of individual mammalian genomes studied by single-cell Hi-C
Tim J. Stevens,Tim J. Stevens,David Lando,Srinjan Basu,Liam P Atkinson,Yang Cao,Steven F. Lee,Martin Leeb,Kai J. Wohlfahrt,Wayne Boucher,Aoife O’Shaughnessy-Kirwan,Julie Cramard,Andre J. Faure,Meryem Ralser,Enrique Blanco,Lluis Morey,Miriam Sansó,Matthieu Palayret,Ben Lehner,Ben Lehner,Ben Lehner,Luciano Di Croce,Luciano Di Croce,Luciano Di Croce,Anton Wutz,Brian Hendrich,Dave Klenerman,Ernest D. Laue +27 more
TL;DR: 3D structures of entire mammalian genomes are calculated using data from a new chromosome conformation capture procedure that allows genome folding to be examined at a scale of less than 100 kb, and chromosome structures to be validated.
Journal ArticleDOI
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.
Peter R. Nielsen,Daniel Nietlispach,Helen R. Mott,Juliana Callaghan,Andrew J. Bannister,Tony Kouzarides,Alexey G. Murzin,Natalia V. Murzina,Ernest D. Laue +8 more
TL;DR: It is shown that HP1 uses an induced-fit mechanism for recognition of methylation of lysine 9 in histone H3, which predicts which other chromodomains will bind methylated proteins and suggest a motif that they recognize.