E
Esmail D. Zanjani
Researcher at United States Department of Veterans Affairs
Publications - 74
Citations - 4602
Esmail D. Zanjani is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Haematopoiesis & Bone marrow. The author has an hindex of 35, co-authored 74 publications receiving 4558 citations. Previous affiliations of Esmail D. Zanjani include University of California, San Francisco & Medical University of South Carolina.
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Journal ArticleDOI
KDR receptor: a key marker defining hematopoietic stem cells.
Benedikt L. Ziegler,Mauro Valtieri,Mauro Valtieri,G. Almeida Porada,R De Maria,R De Maria,Robert Müller,B. Masella,Marco Gabbianelli,Ida Casella,Elvira Pelosi,T. Bock,Esmail D. Zanjani,Cesare Peschle,Cesare Peschle +14 more
TL;DR: KDR is a positive functional marker defining stem cells and distinguishing them from progenitors, comparable to the CD34 marker of hematopoietic progenitor cells.
Journal Article
Human bone marrow CD34- cells engraft in vivo and undergo multilineage expression that includes giving rise to CD34+ cells.
TL;DR: It is demonstrated that the CD34- fraction of normal human bone marrow contains cells capable of engraftment and differentiation into CD34+ progenitors and multiple lymphohematopoietic lineages in primary and secondary hosts.
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Transplantation of fetal hematopoietic stem cells in utero: the creation of hematopoietic chimeras
TL;DR: Transplantation of normal, immature, fetal hematopoietic cells into a preimmune fetal recipient with a congenital hemoglobinopathy may allow partial reconstitution of normal hemoglobin production without the complications associated with postnatal bone marrow transplantation.
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Cotransplantation of human stromal cell progenitors into preimmune fetal sheep results in early appearance of human donor cells in circulation and boosts cell levels in bone marrow at later time points after transplantation.
TL;DR: The cotransplantation of both autologous and allogeneic human bone marrow-derived stromal cell progenitors resulted in an enhancement of long-term engraftment of human cells in the bone marrow of the chimeric animals and in earlier and higher levels of donor cells in circulation both during gestation and after birth.
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Studies of human pluripotential hemopoietic stem cells (CFU-GEMM) in vitro
TL;DR: CFU-GEMM is demonstrated to be a distinct multipotential stem cell class whose assay may prove useful in the study of human blood dyscrasias and in vitro detection requires only relatively low permissive concentrations of Ep.