E
Estelle Piwowar-Manning
Researcher at Johns Hopkins University
Publications - 21
Citations - 7734
Estelle Piwowar-Manning is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 6, co-authored 6 publications receiving 7013 citations. Previous affiliations of Estelle Piwowar-Manning include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more
TL;DR: In this article, Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples.
Journal ArticleDOI
Antiretroviral Therapy for the Prevention of HIV-1 Transmission
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Leslie Cottle,Xinyi C. Zhang,Joseph Makhema,Lisa A. Mills,Ravindre Panchia,Sharlaa Faesen,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Max Essex,Sarah E. Hudelson,Andrew D. Redd,Thomas R. Fleming +35 more
TL;DR: The early initiation of ART led to a sustained decrease in genetically linked HIV-1 infections in sexual partners, and was associated with a 93% lower risk of linked partner infection than was delayed ART.
Journal ArticleDOI
Effects of early versus delayed initiation of antiretroviral treatment on clinical outcomes of HIV-1 infection: results from the phase 3 HPTN 052 randomised controlled trial
Beatriz Grinsztejn,Mina C. Hosseinipour,Heather J. Ribaudo,Susan Swindells,Joseph J. Eron,Ying Q. Chen,Lei Wang,San San Ou,Maija Anderson,Marybeth McCauley,Theresa Gamble,N. Kumarasamy,James Hakim,Johnstone Kumwenda,José Henrique Pilotto,Sheela Godbole,Suwat Chariyalertsak,Marineide Gonçalves de Melo,Kenneth H. Mayer,Susan H. Eshleman,Estelle Piwowar-Manning,Joseph Makhema,Lisa A. Mills,Ravindre Panchia,Ian Sanne,Joel E. Gallant,Irving F. Hoffman,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Max Essex,Diane V. Havlir,Myron S. Cohen +32 more
TL;DR: The clinical benefits recorded, combined with the striking reduction in HIV-1 transmission risk previously reported, provides strong support for earlier initiation of antiretroviral treatment.
Journal ArticleDOI
Analysis of Genetic Linkage of HIV From Couples Enrolled in the HIV Prevention Trials Network 052 Trial
Susan H. Eshleman,Sarah E. Hudelson,Andrew D. Redd,Lei Wang,R. Debes,Ying Q. Chen,Craig Martens,Stacy M. Ricklefs,Ethan J. Selig,Stephen F. Porcella,Supriya Munshaw,Stuart C. Ray,Estelle Piwowar-Manning,Marybeth McCauley,Mina C. Hosseinipour,Johnstone Kumwenda,James Hakim,Suwat Chariyalertsak,Guy de Bruyn,Beatriz Grinsztejn,Nagalingeswaran Kumarasamy,Joseph Makhema,Kenneth H. Mayer,José Henrique Pilotto,Breno Santos,Thomas C. Quinn,Thomas C. Quinn,Myron S. Cohen,James P. Hughes,James P. Hughes +29 more
TL;DR: The association of early ART and reduced HIV transmission was stronger when the analysis included only linked events, and underscores the importance of assessing the genetic linkage of HIV seroconversion events in HIV prevention studies involving serodiscordant couples.
Journal ArticleDOI
Undisclosed Antiretroviral Drug Use in a Multinational Clinical Trial (HIV Prevention Trials Network 052)
Jessica M. Fogel,Lei Wang,Teresa L. Parsons,San San Ou,Estelle Piwowar-Manning,Ying Q. Chen,Victor Mudhune,Mina C. Hosseinipour,Johnstone Kumwenda,James Hakim,Suwat Chariyalertsak,Ravindre Panchia,Ian Sanne,Nagalingeswaran Kumarasamy,Beatriz Grinsztejn,Joseph Makhema,José Henrique Pilotto,Breno Santos,Kenneth H. Mayer,Marybeth McCauley,Theresa Gamble,Namandjé N. Bumpus,Craig W. Hendrix,Myron S. Cohen,Susan H. Eshleman +24 more
TL;DR: ARS drugs were detected in follow-up samples from participants who were not receiving study-administered treatment and may be useful in addition to self-report of ARV drug use in some clinical trial settings.