B
Babs E. Verstrepen
Researcher at Biomedical Primate Research Centre
Publications - 49
Citations - 2196
Babs E. Verstrepen is an academic researcher from Biomedical Primate Research Centre. The author has contributed to research in topics: Virus & Immune system. The author has an hindex of 16, co-authored 40 publications receiving 1694 citations.
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Journal ArticleDOI
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model.
Barry Rockx,Thijs Kuiken,Sander Herfst,Theo M. Bestebroer,Mart M. Lamers,Bas B. Oude Munnink,Dennis de Meulder,Geert van Amerongen,Judith M. A. van den Brand,Nisreen M.A. Okba,Debby Schipper,Peter van Run,Lonneke Leijten,Reina S. Sikkema,Ernst J. Verschoor,Babs E. Verstrepen,Willy M. J. M. Bogers,Jan A.M. Langermans,Jan A.M. Langermans,Christian Drosten,Martje Fentener van Vlissingen,Ron A. M. Fouchier,Rik L. de Swart,Marion Koopmans,Bart L. Haagmans +24 more
TL;DR: Comparisons of three human coronaviruses in cynomolgus macaques show that SARS-CoV-2 causes COVID-19–like disease in macaques and provides a new model to test preventive and therapeutic strategies.
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A Pathogenic Threshold of Virus Load Defined in Simian Immunodeficiency Virus- or Simian-Human Immunodeficiency Virus-Infected Macaques
TL;DR: It is demonstrated that the disease-causing potential was predicted and determined by a threshold plasma virus load which remained greater than 105 RNA equivalents/ml of plasma 6 to 12 weeks after inoculation.
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A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate.
Lorena Sanchez-Felipe,Lorena Sanchez-Felipe,Thomas Vercruysse,Sapna Sharma,Sapna Sharma,Ji Ma,Ji Ma,Viktor Lemmens,Viktor Lemmens,Dominique Van Looveren,Mahadesh Prasad Arkalagud Javarappa,Mahadesh Prasad Arkalagud Javarappa,Robbert Boudewijns,Robbert Boudewijns,Bert Malengier-Devlies,Laurens Liesenborghs,Laurens Liesenborghs,Suzanne J.F. Kaptein,Suzanne J.F. Kaptein,Carolien De Keyzer,Carolien De Keyzer,Lindsey Bervoets,Lindsey Bervoets,Sarah Debaveye,Sarah Debaveye,Madina Rasulova,Laura Seldeslachts,Li Hsin Li,Li Hsin Li,Sander Jansen,Sander Jansen,Michael Bright Yakass,Michael Bright Yakass,Michael Bright Yakass,Babs E. Verstrepen,Kinga P. Böszörményi,Gwendoline Kiemenyi-Kayere,Nikki van Driel,Osbourne Quaye,Osbourne Quaye,Xin Zhang,Xin Zhang,Sebastiaan ter Horst,Sebastiaan ter Horst,Niraj Mishra,Niraj Mishra,Niraj Mishra,Ward Deboutte,Jelle Matthijnssens,Lotte Coelmont,Lotte Coelmont,Corinne Vandermeulen,Elisabeth Heylen,Valentijn Vergote,Dominique Schols,Zhongde Wang,Willy M. J. M. Bogers,Thijs Kuiken,Ernst J. Verschoor,Christopher Cawthorne,Koen Van Laere,Ghislain Opdenakker,Greetje Vande Velde,Birgit Weynand,Dirk E. Teuwen,Patrick Matthys,Johan Neyts,Johan Neyts,Hendrik Jan Thibaut,Kai Dallmeier,Kai Dallmeier +70 more
TL;DR: The quality of immune responses triggered and the rapid kinetics by which protective immunity can be mounted already after a single dose warrant further development of this potent SARS-CoV-2 vaccine candidate.
Journal ArticleDOI
Control of Heterologous Hepatitis C Virus Infection in Chimpanzees Is Associated with the Quality of Vaccine-Induced Peripheral T-Helper Immune Response
Christine S. Rollier,Erik Depla,Joost A. R. Drexhage,Ernst J. Verschoor,Babs E. Verstrepen,A. Fatmi,C. Brinster,Anne Fournillier,J Whelan,Mike Whelan,D. Jacobs,Geert Maertens,Geneviève Inchauspé,Jonathan L. Heeney +13 more
TL;DR: The findings provide data to support the concept that the quality of the response to conserved epitopes and the specific nature of the peripheral T-helper immune response are likely pivotal factors influencing the control and clearance of HCV infection.
Journal ArticleDOI
Upregulation of Indoleamine 2,3-Dioxygenase in Hepatitis C Virus Infection
Esther Larrea,Jose I Riezu-Boj,Lucía Gil-Guerrero,Noelia Casares,Rafael Aldabe,Pablo Sarobe,Maria P. Civeira,Jonathan L. Heeney,Christine S. Rollier,Babs E. Verstrepen,Takaji Wakita,Francisco Borrás-Cuesta,Juan José Lasarte,Jesús Prieto +13 more
TL;DR: In infected chimpanzees, hepatic IDO expression decreased in animals that cured the infection, while it remained high in those that progressed to chronicity, and induction of IDO may dampen T-cell reactivity to viral antigens in chronic HCV infection.