E
Evan W. Weber
Researcher at Stanford University
Publications - 34
Citations - 1600
Evan W. Weber is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & Chimeric antigen receptor. The author has an hindex of 11, co-authored 24 publications receiving 692 citations. Previous affiliations of Evan W. Weber include Northwestern University.
Papers
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Journal ArticleDOI
c-Jun overexpression in CAR T cells induces exhaustion resistance
Rachel C. Lynn,Evan W. Weber,Elena Sotillo,David Gennert,Peng Xu,Zinaida Good,Hima Anbunathan,John Lattin,Robert C. Jones,Victor Tieu,Surya Nagaraja,Jeffrey M. Granja,Charles F. A. de Bourcy,Robbie G. Majzner,Ansuman T. Satpathy,Stephen R. Quake,Michelle Monje,Howard Y. Chang,Howard Y. Chang,Crystal L. Mackall +19 more
TL;DR: It is concluded that a functional deficiency in c-Jun mediates dysfunction in exhausted human T cells, and that engineering CAR T cells to overexpress c- Jun renders them resistant to exhaustion, thereby addressing a major barrier to progress for this emerging class of therapeutic agents.
Journal ArticleDOI
Tuning the Antigen Density Requirement for CAR T-cell Activity.
Robbie G. Majzner,Skyler P. Rietberg,Elena Sotillo,Rui Dong,Vipul T. Vachharajani,Louai Labanieh,June Helen Myklebust,June Helen Myklebust,Meena Kadapakkam,Evan W. Weber,Aidan Tousley,Rebecca Richards,Sabine Heitzeneder,Sang M. Nguyen,Volker Wiebking,Johanna Theruvath,Rachel C. Lynn,Peng Xu,Alexander R. Dunn,Ronald D. Vale,Crystal L. Mackall +20 more
TL;DR: It is demonstrated that CD19 CAR activity is dependent upon antigen density and the CAR construct in axicabtagene-ciloleucel (CD19-CD28z) outperforms that in tisagenlecleucel(CD19) against antigen low tumors and CARs incorporating a CD28-H/T demonstrate a more stable and efficient immunological synapse.
Journal ArticleDOI
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.
Evan W. Weber,Kevin R. Parker,Elena Sotillo,Rachel C. Lynn,Hima Anbunathan,John Lattin,Zinaida Good,Julia A. Belk,Bence Daniel,Dorota Klysz,Meena Malipatlolla,Peng Xu,Malek Bashti,Sabine Heitzeneder,Louai Labanieh,Panayiotis Vandris,Robbie G. Majzner,Yanyan Qi,Katalin Sandor,Ling-chun Chen,Snehit Prabhu,Andrew J. Gentles,Thomas J. Wandless,Ansuman T. Satpathy,Howard Y. Chang,Crystal L. Mackall +25 more
TL;DR: In this paper, the effect of transient cessation of receptor signaling, or rest, on the development and maintenance of T cell exhaustion was investigated using murine xenograft models and an in vitro model wherein tonic CAR signaling induces hallmark features of exhaustion.
Journal ArticleDOI
The Emerging Landscape of Immune Cell Therapies.
TL;DR: This perspective will summarize the current status of immune cell therapies for cancer, infectious disease, and autoimmunity, and discuss advances in cellular engineering to overcome barriers to progress.
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Pharmacologic control of CAR-T cell function using dasatinib.
TL;DR: Dasatinib potently and reversibly suppresses CAR-T cell cytotoxicity, cytokine secretion, and proliferation and could be repurposed as a safety switch to mitigate CAR-mediated toxicity in patients.