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Dorota Klysz
Researcher at Stanford University
Publications - 14
Citations - 933
Dorota Klysz is an academic researcher from Stanford University. The author has contributed to research in topics: Biology & Cancer research. The author has an hindex of 5, co-authored 6 publications receiving 496 citations. Previous affiliations of Dorota Klysz include Centre national de la recherche scientifique & University of Montpellier.
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Journal ArticleDOI
Glutamine-dependent α-ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation
Dorota Klysz,Xuguang Tai,Philippe Robert,Marco Craveiro,Gaspard Cretenet,Leal Oburoglu,Cédric Mongellaz,Stefan Floess,Vanessa Fritz,Maria I. Matias,Carmen S M Yong,Carmen S M Yong,Natalie Surh,Julien C. Marie,Julien C. Marie,Jochen Huehn,Valérie S. Zimmermann,Sandrina Kinet,Valerie Dardalhon,Naomi Taylor +19 more
TL;DR: It is shown that exogenous nutrient availability regulated the differentiation of naïve CD4+ T cells into distinct subsets, and α-ketoglutarate (αKG), the glutamine-derived metabolite that enters into the mitochondrial citric acid cycle, acted as a metabolic regulator of CD4- T cell differentiation.
Journal ArticleDOI
Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification
Leal Oburoglu,Saverio Tardito,Vanessa Fritz,Stéphanie C. De Barros,Peggy Merida,Marco Craveiro,João I. Mamede,Gaspard Cretenet,Cédric Mongellaz,Xiuli An,Xiuli An,Dorota Klysz,Jawida Touhami,Myriam Boyer-Clavel,Jean-Luc Battini,Valérie Dardalhon,Valérie S. Zimmermann,Narla Mohandas,Eyal Gottlieb,Marc Sitbon,Sandrina Kinet,Naomi Taylor +21 more
TL;DR: It is shown that the commitment of human and murine HSCs to the erythroid lineage is dependent upon glutamine metabolism, which regulates HSC lineage commitment under conditions of metabolic stress.
Journal ArticleDOI
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling.
Evan W. Weber,Kevin R. Parker,Elena Sotillo,Rachel C. Lynn,Hima Anbunathan,John Lattin,Zinaida Good,Julia A. Belk,Bence Daniel,Dorota Klysz,Meena Malipatlolla,Peng Xu,Malek Bashti,Sabine Heitzeneder,Louai Labanieh,Panayiotis Vandris,Robbie G. Majzner,Yanyan Qi,Katalin Sandor,Ling-chun Chen,Snehit Prabhu,Andrew J. Gentles,Thomas J. Wandless,Ansuman T. Satpathy,Howard Y. Chang,Crystal L. Mackall +25 more
TL;DR: In this paper, the effect of transient cessation of receptor signaling, or rest, on the development and maintenance of T cell exhaustion was investigated using murine xenograft models and an in vitro model wherein tonic CAR signaling induces hallmark features of exhaustion.
Journal ArticleDOI
Global analysis of shared T cell specificities in human non-small cell lung cancer enables HLA inference and antigen discovery.
Shin Heng Chiou,Diane Tseng,Alexandre Reuben,Vamsee Mallajosyula,Irene S. Molina,Stephanie D. Conley,Julie Wilhelmy,Alana McSween,Xinbo Yang,Daisuke Nishimiya,Rahul Sinha,Barzin Y. Nabet,Chunlin Wang,Joseph B. Shrager,Mark F. Berry,Leah M. Backhus,Natalie S. Lui,Heather A. Wakelee,Joel W. Neal,Sukhmani K. Padda,Gerald J. Berry,Alberto Delaidelli,Poul H. Sorensen,Elena Sotillo,Patrick Tran,Jalen Benson,Rebecca Richards,Louai Labanieh,Dorota Klysz,David M. Louis,Steven A. Feldman,Maximilian Diehn,Irving L. Weissman,Jianjun Zhang,Ignacio I. Wistuba,P. Andrew Futreal,John V. Heymach,K. Christopher Garcia,Crystal L. Mackall,Mark M. Davis +39 more
TL;DR: The findings suggest that this cross-reactivity may underlie the presence of virus-specific T cells in tumor infiltrates and that pathogen cross- reactivity may be a feature of multiple cancers.
Journal ArticleDOI
Enhanced safety and efficacy of protease-regulated CAR-T cell receptors
Louai Labanieh,Robbie G. Majzner,Dorota Klysz,Elena Sotillo,Christopher J. Fisher,Jose G. Vilches-Moure,K. Z. Pacheco,Meena Malipatlolla,Peng Xu,Jessica Hui,Tara Murty,Johanna Theruvath,Nishant Mehta,Sean A. Yamada-Hunter,Evan W. Weber,Sabine Heitzeneder,Kevin R. Parker,Ansuman T. Satpathy,Howard Y. Chang,Michael Z. Lin,Jennifer R. Cochran,Crystal L. Mackall +21 more
TL;DR: SNIP CARs as discussed by the authors is a protease-based platform for regulating CAR activity using an FDA-approved small molecule, and it has been shown that drug cessation following toxicity onset reversed toxicity, thereby credentialing the platform as a safety switch.