F. Sautel

TL;DR: BP 897 inhibits cocaine-seeking behaviour that depends upon the presentation of drug-associated cues, without having any intrinsic, primary rewarding effects, which indicates that compounds like BP 897 could be used for reducing the drug craving and vulnerability to relapse that are elicited by drug- associated environmental stimuli.

TL;DR: The known behavioural actions of D3 selective agonists support a role for the D3 receptor in motor inhibitions, which should be taken into account for the treatment of motor dysfunctions by dopamine agonists.

TL;DR: These studies establish nafadotride as a pure, extremely potent, competitive and preferential dopamine D3 receptor antagonist in vitro.

TL;DR: It is suggested that theDRD3 gene may have a role in drug dependence susceptibility in individuals with high sensation-seeking scores, consistent with the role of DRD3 in mediating responses to drugs of abuse in animals and the association of homozygosity at the Bal I polymorphism with drug abuse in schizophrenic patients.

TL;DR: It is proposed that homozygosity for the Bal I polymorphism DRD3 gene is associated with predisposition to substance abuse and/or the pharmacosensitive characteristic of schizophrenia rather than with schizophrenia itself, an hypothesis in agreement with the positive association of this polymorphism with opiate dependence