F. Thomas Wunderlich

TL;DR: It is shown that the developing DT-specific antibody response is weak and not neutralizing, and thus does not impede the efficacy of DT, and the use of iDTR mice is validated as a tool for cell ablation in vivo.

TL;DR: Conditional gene targeting of murine Phb2 is used to define cellular activities of prohibitins and assign an essential function for the formation of mitochondrial cristae to prohibitingins and suggest a coupling of cell proliferation to mitochondrial morphogenesis.

TL;DR: It is demonstrated that palmitate acting in the central nervous system (CNS) inhibits leptin-induced anorexia and Stat3 activation and defines neuronal MyD88-dependent signaling as a key regulator of diet-induced leptin and insulin resistance in vivo.

TL;DR: It is demonstrated that central insulin action plays an important role in regulating WAT mass and glucose metabolism via hepatic Stat3 activation and chronic intracerebroventricular insulin treatment of control mice increased fat mass, fat cell size, and adipose tissue lipoprotein lipase expression, indicating that CNS insulin action promotes lipogenesis.

TL;DR: The results suggest that AgRP neurons in mice induce not only eating, but also insulin resistance by stimulating expression of muscle-related genes in BAT, revealing a mechanism by which these neurons rapidly coordinate hunger states with glucose homeostasis.