F
Frieder Schwenk
Researcher at Artemis
Publications - 34
Citations - 6157
Frieder Schwenk is an academic researcher from Artemis. The author has contributed to research in topics: Recombinase & Gene. The author has an hindex of 22, co-authored 34 publications receiving 5907 citations. Previous affiliations of Frieder Schwenk include University of Cologne.
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Journal ArticleDOI
Inducible gene targeting in mice
TL;DR: A method of gene targeting that allows the inducible inactivation of a target gene in mice is presented, which uses an interferon-responsive promoter to control the expression of Cre recombinase.
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A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells.
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Conditional gene targeting
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Rapid generation of inducible mouse mutants
Jost Seibler,Branko Zevnik,Birgit Küter-Luks,Susanne Andreas,Heidrun Kern,Thomas Hennek,Anja Rode,Cornelia Heimann,Nicole Faust,Gunther Kauselmann,Michael Schoor,Rudolf Jaenisch,Klaus Rajewsky,Ralf Kühn,Frieder Schwenk +14 more
TL;DR: This work has generated an optimized inducible recombination system for conditional gene targeting based on a Cre recombinase-steroid receptor fusion that allows efficient Cre-mediated recombination in most organs of the mouse upon induction, without detectable background activity.
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Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity
Leona Plum,Xiaosong Ma,Brigitte Hampel,Nina Balthasar,Roberto Coppari,Heike Münzberg,Marya Shanabrough,Denis Burdakov,Eva Rother,Ruth Janoschek,Jens Alber,Bengt F. Belgardt,Linda Koch,Jost Seibler,Frieder Schwenk,Csaba Fekete,Akira Suzuki,Tak W. Mak,Wilhelm Krone,Tamas L. Horvath,Frances M. Ashcroft,Jens C. Brüning +21 more
TL;DR: It is shown that POMC-specific disruption of Pten resulted in hyperphagia and sexually dimorphic diet-sensitive obesity, which indicates that PIP3-mediated signals are critical regulators of the melanocortin system via modulation of KATP channels.