F
F. Van Leuven
Researcher at Katholieke Universiteit Leuven
Publications - 105
Citations - 5923
F. Van Leuven is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Peptide sequence & Amyloid precursor protein. The author has an hindex of 42, co-authored 105 publications receiving 5774 citations. Previous affiliations of F. Van Leuven include Catholic University of Leuven.
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Journal ArticleDOI
Analysis of two novel classes of plant antifungal proteins from radish (Raphanus sativus L.) seeds.
Franky R. G. Terras,Hilde M. E. Schoofs,M. F. C. De Bolle,F. Van Leuven,S B Rees,Jozef Vanderleyden,Bruno P. A. Cammue,Willem F. Broekaert +7 more
TL;DR: The radish 2S storage albumins were identified as the second novel class of antifungal proteins that inhibit growth of different plant pathogenic fungi and some bacteria, however, their antimicrobial activities are strongly antagonized by cations.
Journal ArticleDOI
Antimicrobial peptides from Mirabilis jalapa and Amaranthus caudatus: expression, processing, localization and biological activity in transgenic tobacco
M. F. C. De Bolle,R. W. Osborn,Inge J.W.M. Goderis,L. Noe,D. Acland,C. A. Hart,Sophie Torrekens,F. Van Leuven,Willem F. Broekaert +8 more
TL;DR: In this article, the cDNAs encoding the seed antimicrobial peptides (AMPs) from Mirabilis jalapa (Mj-AMP2) and Amaranthus caudatus (Ac-AMP 2) have been characterized and it was found that AMPs are processed from a precursor preprotein and preproprotein, respectively.
Journal ArticleDOI
Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase furin
A. J. M. Roebroek,Lieve Umans,I. G. L. Pauli,E. J. Robertson,F. Van Leuven,W.J.M. Van de Ven,Daniel B. Constam +6 more
TL;DR: The present data identify Furin as an important activator of signals responsible for ventral closure and embryonic turning as well as cardiac and endodermal marker genes that are compromised.
Journal ArticleDOI
Demonstration of an alpha2-macroglobulin receptor in human fibroblasts, absent in tumor-derived cell lines.
TL;DR: Evidence is provided that two tumor-derived cell lines, which were previously shown to have a low intracellular a2M content under steady state culture conditions, are devoid of the specific azM binding site at their plasma membrane.
Journal ArticleDOI
Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.
TL;DR: The data demonstrate that incomplete or incorrect alpha‐secretase processing of APP results in severe neurotoxicity and that this effect is expressed in a dominant manner.