F
F. Van Leuven
Researcher at Katholieke Universiteit Leuven
Publications - 105
Citations - 5923
F. Van Leuven is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Peptide sequence & Amyloid precursor protein. The author has an hindex of 42, co-authored 105 publications receiving 5774 citations. Previous affiliations of F. Van Leuven include Catholic University of Leuven.
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Journal ArticleDOI
The Major Tuber Storage Protein of Araceae Species Is a Lectin (Characterization and Molecular Cloning of the Lectin from Arum maculatum L.)
TL;DR: Evidence is presented that a previously described major storage protein of Colocasia tubers corresponds to the lectin, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis and gel filtration of the different Araceae lectins have shown that they are tetrameric proteins composed of lectin subunits of 12 to 14 kD.
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Neonatal neuronal overexpression of glycogen synthase kinase-3β reduces brain size in transgenic mice
Kurt Spittaels,C. Van den Haute,J. Van Dorpe,D. Terwel,Kris Vandezande,Reena Lasrado,Koen Bruynseels,M Irizarry,Marleen Verhoye,J Van Lint,Jackie R. Vandenheede,D Ashton,M Mercken,Ruth J. F. Loos,B. T. Hyman,A. Van der Linden,Hugo Geerts,F. Van Leuven +17 more
TL;DR: It is demonstrated that the kinase influenced post-natal maturation and differentiation of neurons in vivo in transgenic mice that overexpress a constitutively active GSK-3beta[S9A], and the overall reduction in size of the entire CNS induced by constitutive active G SK-3 beta caused only very subtle changes in the psychomotoric ability of adult and ageing GSK
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Coexpression of human cdk5 and its activator p35 with human protein tau in neurons in brain of triple transgenic mice.
C. Van den Haute,Kurt Spittaels,J. Van Dorpe,Reena Lasrado,Kris Vandezande,Isabelle Laenen,Hugo Geerts,F. Van Leuven +7 more
TL;DR: Observations indicate that cdk5/p35 is not a major protein tau kinase and that cd k5/ p35 did not cause neurodegeneration in mouse brain, as opposed to cdk 5/p25.
Journal ArticleDOI
GSK3ß, a centre-staged kinase in neuropsychiatric disorders, modulates long term memory by inhibitory phosphorylation at Serine-9
Ilse Dewachter,Laurence Ris,Tomasz Jaworski,Claire M. Seymour,Anneke Kremer,Peter Borghgraef,H De Vijver,Emile Godaux,F. Van Leuven +8 more
TL;DR: A role for GSK3ss in long term memory formation is demonstrated, by inhibitory phosphorylation at Serine-9 following cognitive training in two different hippocampus dependent cognitive tasks, i.e. inhibitory avoidance and novel object recognition task.