F
Fabian Bumbak
Researcher at Florey Institute of Neuroscience and Mental Health
Publications - 14
Citations - 682
Fabian Bumbak is an academic researcher from Florey Institute of Neuroscience and Mental Health. The author has contributed to research in topics: G protein-coupled receptor & Allosteric regulation. The author has an hindex of 7, co-authored 9 publications receiving 535 citations. Previous affiliations of Fabian Bumbak include University of Melbourne & Indiana University.
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Best practices in heterotrophic high-cell-density microalgal processes: achievements, potential and possible limitations
TL;DR: It is confirmed that, although fundamental knowledge is now available, the development of efficient, economically feasible large-scale bioprocesses remains an obstacle to the commercialisation of this promising technology.
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Cultivation strategies to enhance productivity of Pichia pastoris: A review
Verena Looser,Béla Brühlmann,Fabian Bumbak,Chantal Stenger,Merixtell Costa,Andrea Camattari,Dimitrios Fotiadis,Karin Kovar +7 more
TL;DR: This review focuses on particular aspects of recombinant protein production related to variations in biomass growth and their implications for strain design and screening, as well as on the concept of rational comparisons between cultivation systems for the development of specific production processes in bioreactors.
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SYT1-associated neurodevelopmental disorder: a case series
Kate Baker,Kate Baker,Sarah L. Gordon,Holly Melland,Fabian Bumbak,Daniel Scott,Daniel Scott,Tess J. Jiang,David J. Owen,Bradley J. Turner,Stewart Boyd,Mari Rossi,Mohammed Al-Raqad,Orly Elpeleg,Dawn Peck,Grazia M.S. Mancini,Martina Wilke,Marcella Zollino,Giuseppe Marangi,Heike Weigand,Ingo Borggraefe,Tobias B. Haack,Tobias B. Haack,Zornitza Stark,Simon Sadedin,Tiong Yang Tan,Yunyun Jiang,Richard A. Gibbs,Sara Ellingwood,Michelle D. Amaral,Whitley V. Kelley,Manju A. Kurian,Michael A. Cousin,F Lucy Raymond +33 more
TL;DR: The first international case series describing the neurodevelopmental disorder associated with Synaptotagmin 1 (SYT1) de novo missense mutations is presented, which features include movement abnormalities, severe intellectual disability, and hallmark EEG alterations.
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Optimization and 13CH3 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies.
Fabian Bumbak,Alastair C. Keen,Natalie Gunn,Paul R. Gooley,Ross A. D. Bathgate,Ross A. D. Bathgate,Daniel Scott,Daniel Scott +7 more
TL;DR: In this article, the authors investigated the conformational dynamics of neurotensin receptor 1 (NTS1) using solution NMR spectroscopy and found that it exhibited chemical shift changes upon the addition of the high affinity agonist peptide, NT8-13.
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Spontaneous self-assembly of engineered armadillo repeat protein fragments into a folded structure
Randall P. Watson,Martin T. Christen,Christina Ewald,Fabian Bumbak,Christian Reichen,Maja Mihajlovic,Elena Schmidt,Peter Güntert,Amedeo Caflisch,Andreas Plückthun,Oliver Zerbe +10 more
TL;DR: It is proposed that the existence of a stable complex recapitulates possible intermediates in the early evolution of these repeat proteins.