F
Fabián E. Sáenz
Researcher at Facultad de Ciencias Exactas y Naturales
Publications - 23
Citations - 622
Fabián E. Sáenz is an academic researcher from Facultad de Ciencias Exactas y Naturales. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 11, co-authored 20 publications receiving 534 citations. Previous affiliations of Fabián E. Sáenz include University of Notre Dame & University of South Florida.
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Journal ArticleDOI
Quinolone-3-Diarylethers: A New Class of Antimalarial Drug
Aaron Nilsen,Alexis N. LaCrue,Karen L. White,Isaac P. Forquer,R. Matthew Cross,Jutta Marfurt,Michael W. Mather,Michael J. Delves,David M. Shackleford,Fabián E. Sáenz,Joanne M. Morrisey,Jessica Anne Steuten,Tina Mutka,Yuexin Li,Grennady Wirjanata,Eileen Ryan,Sandra Duffy,Jane X. Kelly,Boni F. Sebayang,Anne-Marie Zeeman,Rintis Noviyanti,Robert E. Sinden,Clemens H. M. Kocken,Ric N. Price,Ric N. Price,Vicky M. Avery,Iñigo Angulo-Barturen,María Belén Jiménez-Díaz,Santiago Ferrer,Esperanza Herreros,Laura M. Sanz,Francisco-Javier Gamo,Ian Bathurst,Jeremy N. Burrows,Peter Siegl,R. Kiplin Guy,Rolf W. Winter,Akhil B. Vaidya,Susan A. Charman,Dennis E. Kyle,Roman Manetsch,Michael K. Riscoe +41 more
TL;DR: ELQ-300, a 4(1H)-quinolone-3-diarylether, which targets the liver and blood stages, including the forms that are crucial to disease transmission (gametocytes, zygotes, and ookinetes), has potential as a new drug for the treatment, prevention, and, ultimately, eradication of human malaria.
Journal ArticleDOI
The transmembrane isoform of Plasmodium falciparum MAEBL is essential for the invasion of Anopheles salivary glands.
Fabián E. Sáenz,Fabián E. Sáenz,Bharath Balu,Jonah Smith,Sarita R. Mendonca,Sarita R. Mendonca,John H. Adams +6 more
TL;DR: MAEBL is the first P. falciparum sporozoite ligand experimentally determined to be essential for this important step in the life cycle where the vector becomes infectious for transmitting sporozoites to people and validated as essential for invasion of Anopheles salivary glands.
Journal ArticleDOI
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
Matthew Cross,David L. Flanigan,Andrii Monastyrskyi,Alexis N. LaCrue,Fabián E. Sáenz,Jordany R. Maignan,Tina S. Mutka,Karen L. White,David M. Shackleford,Ian Bathurst,Frank R. Fronczek,Lukasz Wojtas,Wayne C. Guida,Susan A. Charman,Jeremy N. Burrows,Dennis E. Kyle,Roman Manetsch +16 more
TL;DR: Extensive physicochemical evaluation of the quinolone series was carried out to downselect the most promising 4(1H)-quinolones, 7, 62, 66, and 67, which possessed low-nanomolar EC50 values against W2 and TM90-C2B as well as improved microsomal stability.
Journal ArticleDOI
Clonal population expansion in an outbreak of Plasmodium falciparum on the northwest coast of Ecuador
Fabián E. Sáenz,Lindsay Morton,Sheila Okoth,Gabriela Valenzuela,Claudia A. Vera-Arias,Eileen Vélez-Álvarez,Naomi W. Lucchi,L. E Castro,Venkatachalam Udhayakumar +8 more
TL;DR: This study indicates that parasites from a single clonal lineage largely contributed to this outbreak and this lineage was found to be genetically related to a lineage previously reported in the Peruvian coast and historical Ecuadorian parasites.
Journal ArticleDOI
Malaria epidemiology in low-endemicity areas of the northern coast of Ecuador: high prevalence of asymptomatic infections.
Fabián E. Sáenz,Andrea Arévalo-Cortés,Gabriela Valenzuela,Andres F. Vallejo,Angélica Castellanos,Andrea C. Poveda-Loayza,Juan B. Gutierrez,Alvaro Alvarez,Yi Heng Yan,Yoldy Benavides,Luis Enrique Castro,Myriam Arévalo-Herrera,Sócrates Herrera +12 more
TL;DR: Results suggest that despite a great malaria reduction in Ecuador, transition from control to elimination would demand further improvement in malaria diagnostics, including active case detection to identify and treat parasite asymptomatic carriers, as well as community participation in its elimination.