T
Tina Mutka
Researcher at University of South Florida
Publications - 8
Citations - 499
Tina Mutka is an academic researcher from University of South Florida. The author has contributed to research in topics: Artemisinin & Plasmodium yoelii. The author has an hindex of 5, co-authored 8 publications receiving 452 citations. Previous affiliations of Tina Mutka include University of Alabama at Birmingham.
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Journal ArticleDOI
Quinolone-3-Diarylethers: A New Class of Antimalarial Drug
Aaron Nilsen,Alexis N. LaCrue,Karen L. White,Isaac P. Forquer,R. Matthew Cross,Jutta Marfurt,Michael W. Mather,Michael J. Delves,David M. Shackleford,Fabián E. Sáenz,Joanne M. Morrisey,Jessica Anne Steuten,Tina Mutka,Yuexin Li,Grennady Wirjanata,Eileen Ryan,Sandra Duffy,Jane X. Kelly,Boni F. Sebayang,Anne-Marie Zeeman,Rintis Noviyanti,Robert E. Sinden,Clemens H. M. Kocken,Ric N. Price,Ric N. Price,Vicky M. Avery,Iñigo Angulo-Barturen,María Belén Jiménez-Díaz,Santiago Ferrer,Esperanza Herreros,Laura M. Sanz,Francisco-Javier Gamo,Ian Bathurst,Jeremy N. Burrows,Peter Siegl,R. Kiplin Guy,Rolf W. Winter,Akhil B. Vaidya,Susan A. Charman,Dennis E. Kyle,Roman Manetsch,Michael K. Riscoe +41 more
TL;DR: ELQ-300, a 4(1H)-quinolone-3-diarylether, which targets the liver and blood stages, including the forms that are crucial to disease transmission (gametocytes, zygotes, and ookinetes), has potential as a new drug for the treatment, prevention, and, ultimately, eradication of human malaria.
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Epigenetic Tailoring for the Production of Anti-Infective Cytosporones from the Marine Fungus Leucostoma persoonii
Jeremy Beau,Nida Mahid,Whittney N. Burda,Lacey Harrington,Lindsey N. Shaw,Tina Mutka,Dennis E. Kyle,Betty Barisic,Alberto van Olphen,Bill J. Baker +9 more
TL;DR: A strain of marine fungus is isolated that produces bioactive cytosporones and was active against MRSA with a minimal inhibitory concentration (MIC) and inhibition of MRSA biofilm at roughly half that value (minimum biofilm eradication counts, MBEC90, was found to be 39 µM).
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Screening mangrove endophytic fungi for antimalarial natural products.
Laurent Calcul,Carrie Waterman,Wai Sheung Ma,Matthew D. Lebar,Charles Harter,Tina Mutka,Lindsay Morton,Patrick Maignan,Alberto van Olphen,Dennis E. Kyle,Lilian L.P. Vrijmoed,Ka-Lai Pang,Cedric J. Pearce,Bill J. Baker +13 more
TL;DR: An accelerated discovery program based on small-scale cultivation for crude extract screening and a high-throughput malaria assay and criteria for advancing fractions to purification were developed, including the introduction of a selectivity index and by dereplication of known metabolites.
Journal ArticleDOI
Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic sponge Crella sp.
Wai Sheung Ma,Tina Mutka,Brian Vesley,Margaret O. Amsler,James B. McClintock,Charles D. Amsler,Jason A. Perman,Maya P. Singh,William M. Maiese,Michael J. Zaworotko,Dennis E. Kyle,Bill J. Baker +11 more
TL;DR: Five new steroids, norselic acids A-E (1-5), were isolated from the sponge Crella sp.
Journal ArticleDOI
A potent antimalarial trichothecene from hyphomycete species
TL;DR: A new sesquiterpene, trichothecinol D, was isolation and identification, which exhibited potent in vitro activity against Plasmodium falciparum with a 200-fold selectivity for parasite versus mammalian cytotoxicity.