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Alexis N. LaCrue
Researcher at University of South Florida
Publications - 19
Citations - 598
Alexis N. LaCrue is an academic researcher from University of South Florida. The author has contributed to research in topics: Plasmodium falciparum & Plasmodium berghei. The author has an hindex of 10, co-authored 18 publications receiving 537 citations. Previous affiliations of Alexis N. LaCrue include University of Missouri.
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Journal ArticleDOI
Quinolone-3-Diarylethers: A New Class of Antimalarial Drug
Aaron Nilsen,Alexis N. LaCrue,Karen L. White,Isaac P. Forquer,R. Matthew Cross,Jutta Marfurt,Michael W. Mather,Michael J. Delves,David M. Shackleford,Fabián E. Sáenz,Joanne M. Morrisey,Jessica Anne Steuten,Tina Mutka,Yuexin Li,Grennady Wirjanata,Eileen Ryan,Sandra Duffy,Jane X. Kelly,Boni F. Sebayang,Anne-Marie Zeeman,Rintis Noviyanti,Robert E. Sinden,Clemens H. M. Kocken,Ric N. Price,Ric N. Price,Vicky M. Avery,Iñigo Angulo-Barturen,María Belén Jiménez-Díaz,Santiago Ferrer,Esperanza Herreros,Laura M. Sanz,Francisco-Javier Gamo,Ian Bathurst,Jeremy N. Burrows,Peter Siegl,R. Kiplin Guy,Rolf W. Winter,Akhil B. Vaidya,Susan A. Charman,Dennis E. Kyle,Roman Manetsch,Michael K. Riscoe +41 more
TL;DR: ELQ-300, a 4(1H)-quinolone-3-diarylether, which targets the liver and blood stages, including the forms that are crucial to disease transmission (gametocytes, zygotes, and ookinetes), has potential as a new drug for the treatment, prevention, and, ultimately, eradication of human malaria.
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Effects of Artesunate on Parasite Recrudescence and Dormancy in the Rodent Malaria Model Plasmodium vinckei
TL;DR: Data suggest that dormancy occurs in vivo and contributes to recrudescence that is observed following AS treatment, and there is a positive correlation between the number of dormant parasites present and when recrUDescence occurs in the vertebrate host.
Journal ArticleDOI
Fatty Acid Synthesis and Pyruvate Metabolism Pathways Remain Active in Dihydroartemisinin-Induced Dormant Ring Stages of Plasmodium falciparum
Nanhua Chen,Alexis N. LaCrue,Franka Teuscher,Norman C. Waters,Michelle L. Gatton,Dennis E. Kyle,Qin Cheng +6 more
TL;DR: Investigation of transcription of 12 genes encoding key enzymes in various metabolic pathways in P. falciparum during dihydroartemisinin (DHA)-induced dormancy and recovery demonstrates that most metabolic pathways are downregulated in DHA-induced dormant parasites.
Journal ArticleDOI
Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.
Matthew Cross,David L. Flanigan,Andrii Monastyrskyi,Alexis N. LaCrue,Fabián E. Sáenz,Jordany R. Maignan,Tina S. Mutka,Karen L. White,David M. Shackleford,Ian Bathurst,Frank R. Fronczek,Lukasz Wojtas,Wayne C. Guida,Susan A. Charman,Jeremy N. Burrows,Dennis E. Kyle,Roman Manetsch +16 more
TL;DR: Extensive physicochemical evaluation of the quinolone series was carried out to downselect the most promising 4(1H)-quinolones, 7, 62, 66, and 67, which possessed low-nanomolar EC50 values against W2 and TM90-C2B as well as improved microsomal stability.
Journal ArticleDOI
4(1H)-Quinolones with Liver Stage Activity against Plasmodium berghei
Alexis N. LaCrue,Fabián E. Sáenz,R. Matthew Cross,Kenneth O. Udenze,Andrii Monastyrskyi,Steven Stein,Tina S. Mutka,Roman Manetsch,Dennis E. Kyle +8 more
TL;DR: Results showed that all of the compounds were active against liver stage parasites; however, ICI 56,780 and P4Q-158 were the most active, with low nanomolar activity in vitro and causal prophylactic activity in vivo.