F
Fabrice Gorrec
Researcher at Laboratory of Molecular Biology
Publications - 19
Citations - 1401
Fabrice Gorrec is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Protein crystallization & Crystallization. The author has an hindex of 11, co-authored 18 publications receiving 1171 citations. Previous affiliations of Fabrice Gorrec include GlaxoSmithKline.
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Journal ArticleDOI
Type IIA topoisomerase inhibition by a new class of antibacterial agents.
Benjamin D. Bax,Pan F. Chan,Drake S. Eggleston,Drake S. Eggleston,Andrew P. Fosberry,Daniel R. Gentry,Fabrice Gorrec,Fabrice Gorrec,Ilaria Giordano,Michael M. Hann,Alan Joseph Hennessy,Martin Hibbs,Jianzhong Huang,Emma J. Jones,Jo J. Jones,Kristin K. Brown,Ceri J. Lewis,Earl May,Earl May,Martin R. Saunders,Onkar M. P. Singh,Claus Spitzfaden,Carol Shen,Anthony Shillings,Andrew J. Theobald,Alexandre Wohlkonig,Alexandre Wohlkonig,Neil D. Pearson,Michael N. Gwynn +28 more
TL;DR: This work provides new insights into the mechanism of topoisomerase action and a platform for structure-based drug design of a new class of antibacterial agents against a clinically proven, but conformationally flexible, enzyme class.
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The p110[delta] structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
Alex Berndt,Simon Miller,Olusegun Williams,Daniel D Le,Benjamin T. Houseman,Joseph I Pacold,Fabrice Gorrec,Wai-Ching Hon,Pingda Ren,Yi Liu,Christian Rommel,Pascale Gaillard,Thomas Rückle,Matthias Schwarz,Kevan M. Shokat,Jeffrey P. Shaw,Roger L. Williams +16 more
TL;DR: Structures of this enzyme in complex with a broad panel of isoform- and pan-selective class I PI3K inhibitors reveal that selectivity towards p110δ can be achieved by exploiting its conformational flexibility and the sequence diversity of active-site residues that do not contact ATP.
Journal ArticleDOI
The MORPHEUS protein crystallization screen
TL;DR: MORPHEUS is an initial protein crystallization screen with a unique organization which integrates components and ligands selected after analysing all crystal structure data deposited with the Protein Data Bank and local data gathered at the MRC Laboratory of Molecular Biology, Cambridge, England.
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Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly
Anna Herrmannová,Dalia Daujotytė,Ji-Chun Yang,Lucie Cuchalová,Fabrice Gorrec,Susan Wagner,István Dányi,Peter J. Lukavsky,Leoš Shivaya Valášek +8 more
TL;DR: It is concluded that the C-terminus of eIF3b/PRT1 orchestrates co-operative recruitment of eif3i/TIF34 and eIF 3g/Tif35 to the 40S subunit for a stable and proper assembly of 48S pre-initiation complexes necessary for stringent AUG recognition on mRNAs.
Journal ArticleDOI
Corrigendum: The p110[delta] structure: mechanisms for selectivity and potency of new PI(3)K inhibitors
Alex Berndt,Simon Miller,Olusegun Williams,Daniel D Le,Benjamin T. Houseman,Joseph I Pacold,Fabrice Gorrec,Wai-Ching Hon,Pingda Ren,Yi Liu,Christian Rommel,Pascale Gaillard,Thomas Rückle,Matthias Schwarz,Kevan M. Shokat,Jeffrey P. Shaw,Roger L. Williams +16 more
TL;DR: The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors and their applications in drug discovery and drug discovery are described.