Fanny W.F. Shum

TL;DR: It is reported that the activation of the NR2B and NR2A subunits of the NMDA receptor is critical for the induction of cingulate LTP, regardless of the induction protocol.

TL;DR: It is demonstrated that peripheral inflammation increased the expression of NMDA NR2B receptors andNR2B receptor-mediated synaptic currents in the anterior cingulate cortex (ACC) and this contributes to behavioral sensitization caused by inflammation.

TL;DR: It is demonstrated that glutamate and substance P, two principal mediators of sensory information between primary afferent fibers and the spinal cord, activate Erk in dorsal horn neurons of both adult rat and mouse spinal cord.

TL;DR: It is demonstrated that GluR5-containing kainate receptors regulate local inhibitory circuits, modulate the excitatory transmission from the basolateral amygdala to the central amygdala, and control behavioral anxiety.

TL;DR: This work shows that EE enhanced the expression of the plasticity gene, egr-1, in the ACC of EE animals accompanied by enhanced cingulates long-term potentiation (LTP) and decreased cingulate long- term depression (LTD).