F
Farahnaz Sananbenesi
Researcher at University of Göttingen
Publications - 28
Citations - 6371
Farahnaz Sananbenesi is an academic researcher from University of Göttingen. The author has contributed to research in topics: Fear conditioning & Memory consolidation. The author has an hindex of 25, co-authored 27 publications receiving 5886 citations. Previous affiliations of Farahnaz Sananbenesi include Picower Institute for Learning and Memory & Massachusetts Institute of Technology.
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Journal ArticleDOI
Recovery of learning and memory is associated with chromatin remodelling
Andre Fischer,Farahnaz Sananbenesi,Xinyu Wang,Xinyu Wang,Xinyu Wang,Matthew Dobbin,Matthew Dobbin,Matthew Dobbin,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +10 more
TL;DR: It is shown that environmental enrichment reinstated learning behaviour and re-established access to long-term memories after significant brain atrophy and neuronal loss had already occurred, and suggests that inhibition of histone deacetylases might be a suitable therapeutic avenue for neurodegenerative diseases associated with learning and memory impairment.
Journal ArticleDOI
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
Dohoon Kim,Dohoon Kim,Minh Dang Nguyen,Matthew M. Dobbin,Andre Fischer,Farahnaz Sananbenesi,Joseph T. Rodgers,Joseph T. Rodgers,Ivana Delalle,Joseph A. Baur,Guangchao Sui,Sean M. Armour,Pere Puigserver,Pere Puigserver,David A. Sinclair,Li-Huei Tsai +15 more
TL;DR: It is reported that a human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in primary neurons challenged with neurotoxic insults, and provides a promising avenue for therapeutic intervention.
Journal ArticleDOI
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Shahaf Peleg,Farahnaz Sananbenesi,Athanasios Zovoilis,Susanne Burkhardt,Sanaz Bahari-Javan,Roberto Carlos Agis-Balboa,Perla Cota,Jessica Wittnam,Andreas Gogol-Doering,Lennart Opitz,Gabriella Salinas-Riester,Markus Dettenhofer,Hui Kang,Laurent Farinelli,Wei Chen,Andre Fischer +15 more
TL;DR: It is shown that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity, and data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the Aging mouse brain.
Journal ArticleDOI
Targeting the correct HDAC(s) to treat cognitive disorders
Andre Fischer,Farahnaz Sananbenesi,Alison Mungenast,Alison Mungenast,Alison Mungenast,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +7 more
TL;DR: The specific roles of each HDAC protein and the possible function of distinct histone modifications are discussed, in the hope that this knowledge will aid in the development of diagnostic tools and in designing more potent and specific treatment for neurological disorders targeting selective HDAC proteins.
Journal ArticleDOI
microRNA‐34c is a novel target to treat dementias
Athanasios Zovoilis,Hope Y Agbemenyah,Roberto Carlos Agis-Balboa,Roman M. Stilling,Dieter Edbauer,Pooja Rao,Laurent Farinelli,Ivana Delalle,Andrea Schmitt,Andrea Schmitt,Peter Falkai,Peter Falkai,Sanaz Bahari-Javan,Susanne Burkhardt,Farahnaz Sananbenesi,Andre Fischer,Andre Fischer +16 more
TL;DR: The data suggest that miR‐34c could be a marker for the onset of cognitive disturbances linked to AD and indicate that targeting miR-34ccould be a suitable therapy.