microRNA‐34c is a novel target to treat dementias
Athanasios Zovoilis,Hope Y Agbemenyah,Roberto Carlos Agis-Balboa,Roman M. Stilling,Dieter Edbauer,Pooja Rao,Laurent Farinelli,Ivana Delalle,Andrea Schmitt,Andrea Schmitt,Peter Falkai,Peter Falkai,Sanaz Bahari-Javan,Susanne Burkhardt,Farahnaz Sananbenesi,Andre Fischer,Andre Fischer +16 more
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TLDR
The data suggest that miR‐34c could be a marker for the onset of cognitive disturbances linked to AD and indicate that targeting miR-34ccould be a suitable therapy.Abstract:
MicroRNAs are key regulators of transcriptome plasticity and have been implicated with the pathogenesis of brain diseases. Here, we employed massive parallel sequencing and provide, at an unprecedented depth, the complete and quantitative miRNAome of the mouse hippocampus, the prime target of neurodegenerative diseases such as Alzheimer's disease (AD). Using integrative genetics, we identify miR-34c as a negative constraint of memory consolidation and show that miR-34c levels are elevated in the hippocampus of AD patients and corresponding mouse models. In line with this, targeting miR-34 seed rescues learning ability in these mouse models. Our data suggest that miR-34c could be a marker for the onset of cognitive disturbances linked to AD and indicate that targeting miR-34c could be a suitable therapy.read more
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The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila
Nan Liu,Michael Landreh,Michael Landreh,Kajia Cao,Masashi Abe,Gert-Jan Hendriks,Jason R. Kennerdell,Yongqing Zhu,Li-San Wang,Nancy M. Bonini,Nancy M. Bonini +10 more
TL;DR: It is reported that the conserved miRNA miR-34 regulates age-associated events and long-term brain integrity in Drosophila, providing a molecular link between ageing and neurodegeneration.
Journal ArticleDOI
MicroRNAs in neuronal function and dysfunction.
Heh-In Im,Paul J. Kenny +1 more
TL;DR: Evidence suggesting that dysfunction in miRNA signaling contributes to neurodevelopment disorders such as Rett and fragile X syndromes, as well as complex behavioral disorders including schizophrenia, depression and drug addiction is reviewed.
Journal ArticleDOI
Adult-specific functions of animal microRNAs
Kailiang Sun,Eric C. Lai +1 more
TL;DR: This Review examines evidence that miRNAs have continuous roles in adults in ways that are separable from developmental control and discusses methods for studying miRNA activities specifically in adults and evaluate their relative strengths and weaknesses.
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Profiles of Extracellular miRNA in Cerebrospinal Fluid and Serum from Patients with Alzheimer's and Parkinson's Diseases Correlate with Disease Status and Features of Pathology
Kasandra Burgos,Ivana Malenica,Raghu Metpally,Amanda Courtright,Benjamin Rakela,Thomas G. Beach,Holly A. Shill,Charles H. Adler,Marwan N. Sabbagh,Stephen Villa,Waibhav Tembe,David Craig,Kendall Van Keuren-Jensen +12 more
TL;DR: Data indicate that extracellular miRNAs detectable in the cerebrospinal fluid and serum are reflective of cell-based changes in pathology and can be used to assess disease progression and therapeutic efficacy.
Journal ArticleDOI
The epigenetics of aging and neurodegeneration.
Roy Lardenoije,Artemis Iatrou,Gunter Kenis,Konstantinos Kompotis,Harry W.M. Steinbusch,Diego Mastroeni,Paul D. Coleman,Cynthia A. Lemere,Patrick R. Hof,Daniel L.A. van den Hove,Bart P. F. Rutten +10 more
TL;DR: Current knowledge about the major epigenetic mechanisms, including DNA methylation and DNA demethylation, chromatin remodeling and non-coding RNAs, as well as the involvement of these mechanisms in normal aging and in the pathophysiology of the most common neurodegenerative diseases are reviewed.
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