Farideh Z. Bischoff

TL;DR: The National Institute of Child Health and Human Development Fetal Cell Isolation Study (NIFTY) is a prospective, multicenter clinical project to develop non‐invasive methods of prenatal diagnosis.

TL;DR: A parabiosis model is used that demonstrates preferential hematogenous metastasis of ovarian cancer to the omentum and reveals that the ErbB3-neuregulin 1 (NRG1) axis is a dominant pathway responsible for hematogeneous omental metastasis.

TL;DR: A micro-fluidic system, not limited to EpCAM or CK, was developed to use multiple antibodies for capture followed by detection using CEE-Enhanced (CE), a novel in situ staining method that fluorescently labels the capture antibodies bound to CTCs.

TL;DR: Evidence of mutations in the tumour suppressor PTEN gene in the endometrioid subtype of epithelial ovarian cancer further suggests that somatic genetic alterations represent early events in the transformation of benign endometRIotic cells.

TL;DR: It is shown that the primary epithelial tumors were characterized by similar complex aneuploidy, indicating conversion to an EMT phenotype in the captured cells, and this study provides a new method for highly efficient capture of previously unrecognized populations of CTCs.