S
Sinuhe Hahn
Researcher at University Hospital of Basel
Publications - 220
Citations - 12154
Sinuhe Hahn is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Cell-free fetal DNA & Prenatal diagnosis. The author has an hindex of 58, co-authored 220 publications receiving 11368 citations. Previous affiliations of Sinuhe Hahn include Sequenom, Inc. & University of Basel.
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Journal ArticleDOI
Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis-mediated cell death
Anurag Gupta,Manjunath B. Joshi,Maria Philippova,Paul Erne,Paul Hasler,Sinuhe Hahn,Therese J. Resink +6 more
TL;DR: Findings offer new insight into mechanisms whereby NETs trigger damage to the endothelium in sepsis, small vessel vasculitis and possibly the villous trophoblast in preeclampsia.
Journal Article
Fas antigen is the major target molecule for CD4+ T cell-mediated cytotoxicity.
T Stalder,Sinuhe Hahn,Peter Erb +2 more
TL;DR: Although the bulk of CD4+ T cell-mediated lysis appears to be Fas induced, the fact that the effector phase of A20.2J lysis is only partially Ca2+ independent indicates that other pathways also contribute to target cell death.
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Induction of Neutrophil Extracellular DNA Lattices by Placental Microparticles and IL-8 and Their Presence in Preeclampsia
TL;DR: Large numbers of NETs were present directly in the intervillous space of preeclamptic placentae, and their increased presence in preeclampsia suggests that NETs may play a role in the underlying pathology.
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Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data
Diana W. Bianchi,Joe Leigh Simpson,Laird G. Jackson,Sherman Elias,Wolfgang Holzgreve,Mark I. Evans,Kimberly A. Dukes,Lisa M. Sullivan,Katherine W. Klinger,Farideh Z. Bischoff,Sinuhe Hahn,Kirby L. Johnson,Dorothy E. Lewis,Ronald J. Wapner,F. de la Cruz +14 more
TL;DR: The National Institute of Child Health and Human Development Fetal Cell Isolation Study (NIFTY) is a prospective, multicenter clinical project to develop non‐invasive methods of prenatal diagnosis.
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Size Separation of Circulatory DNA in Maternal Plasma Permits Ready Detection of Fetal DNA Polymorphisms
TL;DR: Circulatory fetal DNA can be enriched by size selection of fragment sizes less than approximately 0.3 kb, which permits easier analysis of both paternally and maternally inherited DNA polymorphisms.