F
Fatmah A.M. Al-Omary
Researcher at King Saud University
Publications - 43
Citations - 865
Fatmah A.M. Al-Omary is an academic researcher from King Saud University. The author has contributed to research in topics: Natural bond orbital & Molecule. The author has an hindex of 14, co-authored 39 publications receiving 710 citations.
Papers
More filters
Journal ArticleDOI
Non-classical antifolates. Part 2: Synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones
Fatmah A.M. Al-Omary,Laila A. Abou-Zeid,Mahmoud N. Nagi,El-Sayed E. Habib,Alaa A.-M. Abdel-Aziz,Adel S. El-Azab,Sami G. Abdel-Hamide,Mohamed A. Al-Omar,Abdulrahman M. Al-Obaid,Hussein I. El-Subbagh +9 more
TL;DR: A new series of 2,6-substituted-quinazolin-4-ones was designed, synthesized, and evaluated for their in vitro DHFR inhibition, antimicrobial, and antitumor activities and proved critical for biological activity.
Journal ArticleDOI
Substituted thiazoles V. Synthesis and antitumor activity of novel thiazolo[2,3-b]quinazoline and pyrido[4,3-d]thiazolo[3,2-a]pyrimidine analogues
Fatmah A.M. Al-Omary,Ghada S. Hassan,Ghada S. Hassan,Shahenda M. El-Messery,Hussein I. El-Subbagh +4 more
TL;DR: A novel series of thiazolo[2,3-b]quinazoline (14-23, 26 and 27), and pyrido[4,4-d]thiazolo [3,2-a]pyrimidine analogues were designed and synthesized, and showed remarkable broad-spectrum antitumor activity.
Journal ArticleDOI
Substituted thiazoles VII. Synthesis and antitumor activity of certain 2-(substituted amino)-4-phenyl-1,3-thiazole analogs
Ghada S. Hassan,Ghada S. Hassan,Shahenda M. El-Messery,Fatmah A.M. Al-Omary,Hussein I. El-Subbagh +4 more
TL;DR: A novel series of 2-acetamido- or 2-propanamido -4-(4-substituted phenyl)-1,3-thiazoles (11-34) was designed and synthesized, and compounds 19 and 28 proved to be nine and sevenfold more active than the standard antitumor drug 5-FU, respectively.
Journal ArticleDOI
Nonclassical antifolates, part 4. 5-(2-aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: synthesis, biological evaluation and molecular modeling study.
Ghada S. Hassan,Ghada S. Hassan,Shahenda M. El-Messery,Fatmah A.M. Al-Omary,Sarah T. Al-Rashood,Marwa I. Shabayek,Yasmin S. Abulfadl,El-Sayed E. Habib,Salwa M. El-Hallouty,Walid Fayad,Khaled M. Mohamed,Bassem S. El-Menshawi,Hussein I. El-Subbagh +12 more
TL;DR: Molecular modeling studies concluded that recognition with key amino acid Leu4 and Val1 is essential for DHFR binding, and the obtained model could be useful for the development of new class of DHFR inhibitors.
Journal ArticleDOI
Substituted thiazoles VI. Synthesis and antitumor activity of new 2-acetamido- and 2 or 3-propanamido-thiazole analogs
Shahenda M. El-Messery,Ghada S. Hassan,Ghada S. Hassan,Fatmah A.M. Al-Omary,Hussein I. El-Subbagh +4 more
TL;DR: A novel series of 2-acetamido and 2 or 3-propanamido derivatives of 4- or 5-substituted-thiazoles was designed and synthesized and proved to be more active than their branched or 4-methyl congeners.