F
Fausto Chiazza
Researcher at University of Turin
Publications - 54
Citations - 1715
Fausto Chiazza is an academic researcher from University of Turin. The author has contributed to research in topics: Inflammasome & Insulin resistance. The author has an hindex of 24, co-authored 53 publications receiving 1249 citations. Previous affiliations of Fausto Chiazza include University of Eastern Piedmont & Boston Children's Hospital.
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Journal ArticleDOI
The NLRP3 Inflammasome as a novel player of the intercellular crosstalk in metabolic disorders.
TL;DR: A perspective on the current research on NLRP3 inflammasome is provided, which may represent an innovative therapeutic target to reverse the detrimental metabolic consequences of the metabolic inflammation.
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Pharmacological Inhibition of NLRP3 Inflammasome Attenuates Myocardial Ischemia/Reperfusion Injury by Activation of RISK and Mitochondrial Pathways.
Raffaella Mastrocola,Claudia Penna,Francesca Tullio,Saveria Femminò,Debora Nigro,Fausto Chiazza,Loredana Serpe,Debora Collotta,Giuseppe Alloatti,Mattia Cocco,Massimo Bertinaria,Pasquale Pagliaro,Manuela Aragno,Massimo Collino +13 more
TL;DR: It is demonstrated for the first time that INF4E protected against the IR-induced myocardial injury and dysfunction, by a mechanism that involves inhibition of the NLRP3 inflammasome, resulting in the activation of the prosurvival RISK pathway and improvement in mitochondrial function.
Journal ArticleDOI
Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice
Elisa Benetti,Raffaella Mastrocola,Fausto Chiazza,Debora Nigro,Giuseppe D'Antona,Valentina Bordano,Roberto Fantozzi,Manuela Aragno,Massimo Collino,Marco Alessandro Minetto +9 more
TL;DR: Data indicate that vitamin D-induced selective inhibition of signaling pathways (including NF-κB, SCAP/SREBP and CML/RAGE cascades) within the skeletal muscle significantly contributed to the beneficial effects of vitamin D supplementation against diet-induced metabolic derangements.
Journal ArticleDOI
Acute treatment with relaxin protects the kidney against ischaemia/reperfusion injury
Massimo Collino,Mara Rogazzo,Alessandro Pini,Elisa Benetti,Arianna Carolina Rosa,Fausto Chiazza,Roberto Fantozzi,Daniele Bani,Emanuela Masini +8 more
TL;DR: It is reported herein that rhRLX protects the kidney against I/R injury by a mechanism that involves changes in nitric oxide signalling pathway.
Journal ArticleDOI
Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage
Andrew Aswani,Joanna Manson,Kiyoshi Itagaki,Fausto Chiazza,Massimo Collino,Winston Liao Wupeng,Tze Khee Chan,W.S. Fred Wong,Carl J. Hauser,Chris Thiemermann,Karim Brohi +10 more
TL;DR: It is shown that the release of mtDNA is sufficient for the development of multiple organ injury and neutralizing mtDNA with the nucleic acid scavenging polymer, hexadimethrine bromide (HDMBr), at a clinically relevant time point in vivo would reduce the severity of organ injury in this model.